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1.B.1.1.12
High conductance Omp35 (OmpK35; OmpF) porin.  Expression levels are important for beta-lactam/cephalosporin resistance (Bornet et al. 2004).  95% identical to the Klebsiella pneumoniae orthologue, OmpK35 (Taherpour and Hashemi 2013). In K. pneumoniae, colistin-based combination therapy with a carbapenem and/or tigecycline was associated with significantly decreased mortality rates due in part to synergistic induction of porins K35 and K36 (Stein et al. 2015). They influence imipenem susceptibility as well (Wassef et al. 2015). These two porins play roles in conferring carbapenem resistance in K. pneumoniae (Hamzaoui et al. 2018; Ye et al. 2018).

Accession Number:Q6RW54
Protein Name:Outer membrane porin protein
Length:358
Molecular Weight:39415.00
Species:Enterobacter aerogenes [548]
Number of TMSs:1
Substrate Beta-lactam antibiotics, Cephalosporin, Imipenem

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKRNILAVVI PALLVAGAAN AAEIYNKNGN KLDFYGKMVG EHVWTTNGDT SSDDTTYARI 
61:	GLKGETQIND QLIGYGQWEY NMDASNVEGS QTTKTRLAFA GLKAGEYGSF DYGRNYGAIY 
121:	DVESATDMLV EWGGDGWNYT DNFMTGRTNG VATYRNSDFF GLVDGLSFAL QYQGKNDHDR 
181:	SIRKQNGDGF STAATYAFDN GIALSAGYAN SNRSVDQKRD GNGDKAEAWA TSAKYDANNI 
241:	YAAVMYSQTY NMTPEEDDHF AGKTQNFEAV VQYQFDFGLR PSLGYVQTKG KNLQARGGFG 
301:	GGDADLVKYV ELGTWYYFNK NMNVYAAYKF NQLDDNAYTR AAGVATDDQA AVGIVYQF