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1.B.1.1.24
Porin 2 (Omp-Pst2 or OmpPst2) of 365 aas.  Voltage gating is observed for Omp-Pst2, where the binding of cations in-between L3 and the barrel wall results in exposing a conserved aromatic residue in the channel lumen, thereby halting ion permeation. Comparison of Omp-Pst1 (TC# 1.B.1.1.20) with Omp-Pst2 suggested that their differing sensitivities to voltage is encoded in the hydrogen-bonding network anchoring L3 onto the barrel wall. The strength of this network governs the probability of cations binding behind L3. That Omp-Pst2 gating is observed only when ions flow against the electrostatic potential gradient of the channel suggests a possible role for this porin in the regulation of charge distribution across the outer membrane and bacterial homeostasis (Song et al. 2015).

Accession Number:E3U905
Protein Name:Porin 2
Length:365
Molecular Weight:40186.00
Species:Providencia stuartii [588]
Number of TMSs:1
Substrate small molecules

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FASTA formatted sequence
1:	MKKKTILAVT ICTLFAAGVT NAAEVYNKDG NKLDVYGQID VRHYFADAKS GEDGDDSRVR 
61:	LGFKGDTQIT DQLIGFGRFE WETSTNKAET SNDNQNRLAY AGLKFADYGS LDYGRNYGVI 
121:	YDTNAWTDVL PLWGADTMDQ EDTFMMGRNR NLLTYRNNNG FGYIDGLSFA LQYQGKNGDQ 
181:	NKSTGSSALD NNGDGYGFST AYELGWGLSI GGGYSNSSRT PSQNNIKTGA TGKRAEAWNV 
241:	GSKLELDELY LAAMYGQTLN TTRFGDDDAE AIANKTENLE LVALYSFDFG LTPSIGYNQS 
301:	KGKNLGNYGN KDLVKYIAVG ASYDFNKNMA AVIDYKINLL KDNQFTDDYG INTDNVLGLG 
361:	LIYQF