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1.B.1.1.3
OmpC general porin.  Expression of OmpC and OmpF is reciprocally regulated by the EnvZ/OmpR sensor kinase/response regulator system (Egger et al. 1997).  Mutants isolated from patients with MDR E. coli, resistant to several antibiotics, showed decreased permeability to these antibiotics (Lou et al. 2011). The diffusion route of the fluoroquinolone, enrofloxacin, through the OmpC porin has been reported (Prajapati et al. 2018).

Accession Number:P06996
Protein Name:OmpC aka MEOA aka PAR aka B2215
Length:367
Molecular Weight:40368.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate antibiotics, Solutes

Cross database links:

Genevestigator: P06996
EchoBASE: EB0664
EcoGene: EG10670
eggNOG: COG3203
HEGENOM: HBG673855
DIP: DIP-10397N
RefSeq: AP_002811.1    NP_416719.1   
Entrez Gene ID: 946716   
Pfam: PF00267   
BioCyc: EcoCyc:EG10670-MONOMER    ECOL168927:B2215-MONOMER   
KEGG: ecj:JW2203    eco:b2215   

Gene Ontology

GO:0045203 C:integral to cell outer membrane
GO:0005886 C:plasma membrane
GO:0046930 C:pore complex
GO:0005515 F:protein binding
GO:0005215 F:transporter activity
GO:0009597 P:detection of virus
GO:0046718 P:entry of virus into host cell
GO:0006811 P:ion transport

References (8)

[1] “A comparative study on the genes for three porins of the Escherichia coli outer membrane. DNA sequence of the osmoregulated ompC gene.”  Mizuno T.et.al.   6304064
[2] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “DNA sequence of the promoter region of the ompC gene and the amino acid sequence of the signal peptide of pro-OmpC protein of Escherichia coli.”  Mizuno T.et.al.   6297988
[6] “Construction of a series of ompF-ompC chimeric genes by in vivo homologous recombination in Escherichia coli and characterization of the translational products.”  Nogami T.et.al.   2997131
[7] “Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.”  Link A.J.et.al.   9298646
[8] “Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.”  Molloy M.P.et.al.   9629924
Structure:
2J1N   2J4U   2ZLE   3NB3   4A8D     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKVKVLSLLV PALLVAGAAN AAEVYNKDGN KLDLYGKVDG LHYFSDNKDV DGDQTYMRLG 
61:	FKGETQVTDQ LTGYGQWEYQ IQGNSAENEN NSWTRVAFAG LKFQDVGSFD YGRNYGVVYD 
121:	VTSWTDVLPE FGGDTYGSDN FMQQRGNGFA TYRNTDFFGL VDGLNFAVQY QGKNGNPSGE 
181:	GFTSGVTNNG RDALRQNGDG VGGSITYDYE GFGIGGAISS SKRTDAQNTA AYIGNGDRAE 
241:	TYTGGLKYDA NNIYLAAQYT QTYNATRVGS LGWANKAQNF EAVAQYQFDF GLRPSLAYLQ 
301:	SKGKNLGRGY DDEDILKYVD VGATYYFNKN MSTYVDYKIN LLDDNQFTRD AGINTDNIVA 
361:	LGLVYQF