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1.B.1.1.4
Weakly anion-selective NmpC (OmpD) porin (Prilipov et al. 1998).  Transports methyl benzyl viologen, ceftriaxone and hydrogen peroxide in Salmonella species (Hu et al. 2011; Calderón et al. 2010).

Accession Number:P21420
Protein Name:NmpC aka PHMA aka B0553
Length:365
Molecular Weight:40302.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate anions, Methylbenzylviologen, Ceftriaxone, H2O2

Cross database links:

Genevestigator: P21420
EchoBASE: EB0653
EcoGene: EG10659
Pfam: PF00267   
BioCyc: EcoCyc:EG10659-MONOMER    ECOL168927:B0553-MONOMER   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0046930 C:pore complex
GO:0005215 F:transporter activity
GO:0006811 P:ion transport

References (4)

[1] “Structure of the lc and nmpC outer membrane porin protein genes of lambdoid bacteriophage.”  Blasband A.J.et.al.   3017988
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Expression of the nmpC gene of Escherichia coli K-12 is modulated by external pH. Identification of cis-acting regulatory sequences involved in this regulation.”  Coll J.L.et.al.   8057841
[4] “Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82.”  Mahdi A.A.et.al.   8648624

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKLTVAISA VAASVLMAMS AQAAEIYNKD SNKLDLYGKV NAKHYFSSND ADDGDTTYAR 
61:	LGFKGETQIN DQLTGFGQWE YEFKGNRAES QGSSKDKTRL AFAGLKFGDY GSIDYGRNYG 
121:	VAYDIGAWTD VLPEFGGDTW TQTDVFMTQR ATGVATYRNN DFFGLVDGLN FAAQYQGKND 
181:	RSDFDNYTEG NGDGFGFSAT YEYEGFGIGA TYAKSDRTDT QVNAGKVLPE VFASGKNAEV 
241:	WAAGLKYDAN NIYLATTYSE TQNMTVFADH FVANKAQNFE AVAQYQFDFG LRPSVAYLQS 
301:	KGKDLGVWGD QDLVKYVDVG ATYYFNKNMS TFVDYKINLL DKNDFTKALG VSTDDIVAVG 
361:	LVYQF