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1.B.10.1.1
Nucleoside-specific channel forming protein, Tsx (Benz et al. 1988).

Accession Number:P0A927
Protein Name:Nucleoside-specific channel-forming protein Tsx aka NUPA aka B0411
Length:294
Molecular Weight:33589.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Nucleosides

Cross database links:

Genevestigator: P0A927
EchoBASE: EB1028
EcoGene: EG11035
eggNOG: COG3248
HEGENOM: HBG416540
RefSeq: AP_001061.1    NP_414945.1   
Entrez Gene ID: 946242   
Pfam: PF03502   
Drugbank: Drugbank Link   
BioCyc: EcoCyc:EG11035-MONOMER    ECOL168927:B0411-MONOMER   
KEGG: ecj:JW0401    eco:b0411   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0046930 C:pore complex
GO:0005337 F:nucleoside transmembrane transporter activity
GO:0009597 P:detection of virus
GO:0046718 P:entry of virus into host cell
GO:0006811 P:ion transport

References (4)

[1] “Analysis of the tsx gene, which encodes a nucleoside-specific channel-forming protein (Tsx) in the outer membrane of Escherichia coli.”  Bremer E.et.al.   2265760
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Analysis of a mutated phage T6 receptor protein of Escherichia coli K 12.”  Maier C.et.al.   2199819
Structure:
1TLW   1TLY   1TLZ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKTLLAAGA VLALSSSFTV NAAENDKPQY LSDWWHQSVN VVGSYHTRFG PQIRNDTYLE 
61:	YEAFAKKDWF DFYGYADAPV FFGGNSDAKG IWNHGSPLFM EIEPRFSIDK LTNTDLSFGP 
121:	FKEWYFANNY IYDMGRNKDG RQSTWYMGLG TDIDTGLPMS LSMNVYAKYQ WQNYGAANEN 
181:	EWDGYRFKIK YFVPITDLWG GQLSYIGFTN FDWGSDLGDD SGNAINGIKT RTNNSIASSH 
241:	ILALNYDHWH YSVVARYWHD GGQWNDDAEL NFGNGNFNVR STGWGGYLVV GYNF