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1.B.11.2.1
Type π fimbrial usher, PapC. The crystal structure of the PapC usher translocation domain has been solved (Daniels and Normark, 2008; Remaut et al., 2008).

Accession Number:P07110
Protein Name:PapC
Length:836
Molecular Weight:91509.00
Species:Escherichia coli [562]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Fimbrial subunits

Cross database links:

Pfam: PF00577   
Drugbank: Drugbank Link   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (6)

[1] “Nucleotide sequence, regulation and functional analysis of the papC gene required for cell surface localization of Pap pili of uropathogenic Escherichia coli.”  Norgren M.et.al.   2897064
[2] “Horizontal gene transfer of the Escherichia coli pap and prs pili operons as a mechanism for the development of tissue-specific adhesive properties.”  Marklund B.-I.et.al.   1357526
[3] “Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis.”  Thanassi D.G.et.al.   12399496
[4] “PapD, a periplasmic transport protein in P-pilus biogenesis.”  Lindberg F.et.al.   2572580
[5] “Chaperone-assisted self-assembly of pili independent of cellular energy.”  Jacob-Dubuisson F.et.al.   7909802
[6] “The PapC usher forms an oligomeric channel: implications for pilus biogenesis across the outer membrane.”  Thanassi D.G.et.al.   9501230
Structure:
2VQI   3FIP   2KT6     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKDRIPFAVN NITCVILLSL FCNAASAVEF NTDVLDAADK KNIDFTRFSE AGYVLPGQYL 
61:	LDVIVNGQSI SPASLQISFV EPALSGDKAE KKLPQACLTS DMVRLMGLTA ESLDKVVYWH 
121:	DGQCADFHGL PGVDIRPDTG AGVLRINMPQ AWLEYSDATW LPPSRWDDGI PGLMLDYNLN 
181:	GTVSRNYQGG DSHQFSYNGT VGGNLGPWRL RADYQGSQEQ SRYNGEKTTN RNFTWSRFYL 
241:	FRAIPRWRAN LTLGENNINS DIFRSWSYTG ASLESDDRML PPRLRGYAPQ ITGIAETNAR 
301:	VVVSQQGRVL YDSMVPAGPF SIQDLDSSVR GRLDVEVIEQ NGRKKTFQVD TASVPYLTRP 
361:	GQVRYKLVSG RSRGYGHETE GPVFATGEAS WGLSNQWSLY GGAVLAGDYN ALAAGAGWDL 
421:	GVPGTLSADI TQSVARIEGE RTFQGKSWRL SYSKRFDNAD ADITFAGYRF SERNYMTMEQ 
481:	YLNARYRNDY SSREKEMYTV TLNKNVADWN TSFNLQYSRQ TYWDIRKTDY YTVSVNRYFN 
541:	VFGLQGVAVG LSASRSKYLG RDNDSAYLRI SVPLGTGTAS YSGSMSNDRY VNMAGYTDTF 
601:	NDGLDSYSLN AGLNSGGGLT SQRQINAYYS HRSPLANLSA NIASLQKGYT SFGVSASGGA 
661:	TITGKGAALH AGGMSGGTRL LVDTDGVGGV PVDGGQVVTN RWGTGVVTDI SSYYRNTTSV 
721:	DLKRLPDDVE ATRSVVESAL TEGAIGYRKF SVLKGKRLFA ILRLADGSQP PFGASVTSEK 
781:	GRELGMVADE GLAWLSGVTP GETLSVNWDG KIQCQVNVPE TAISDQQLLL PCTPQK