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1.B.12.1.1
Autotransporter of adhesin involved in diffuse adherence, AidA (Charbonneau and Mourez, 2007). Heptosylated on 16 ser and thr residues which is required for adhesion (Charbonneau et al., 2007).

Accession Number:Q03155
Protein Name:AidA aka AIDA-I
Length:1286
Molecular Weight:132272.00
Species:Escherichia coli [562]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Adhesins

Cross database links:

Pfam: PF03797   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0005576 C:extracellular region
GO:0016021 C:integral to membrane
GO:0042597 C:periplasmic space
GO:0005886 C:plasma membrane
GO:0005515 F:protein binding
GO:0007155 P:cell adhesion
GO:0009405 P:pathogenesis

References (5)

[1] “AIDA-I, the adhesin involved in diffuse adherence of the diarrhoeagenic Escherichia coli strain 2787 (O126:H27), is synthesized via a precursor molecule.”  Benz I.et.al.   1625582
[2] “Characterization and immuno-detection of AIDA-I adhesin isolated from porcine Escherichia coli.”  Fang Y.et.al.   15950405
[3] “Processing of the AIDA-I precursor: removal of AIDAc and evidence for the outer membrane anchoring as a beta-barrel structure.”  Suhr M.et.al.   8899706
[4] “Characterization of the essential transport function of the AIDA-I autotransporter and evidence supporting structural predictions.”  Maurer J.et.al.   10559167
[5] “Novel roles for the AIDA adhesin from diarrheagenic Escherichia coli: cell aggregation and biofilm formation.”  Sherlock O.et.al.   15547278
Structure:
4MEE     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKAYSIIWS HSRQAWIVAS ELARGHGFVL AKNTLLVLAV VSTIGNAFAV NISGTVSSGG 
61:	TVSSGETQIV YSGRGNSNAT VNSGGTQIVN NGGKTTATTV NSSGSQNVGT SGATISTIVN 
121:	SGGIQRVSSG GVASATNLSG GAQNIYNLGH ASNTVIFSGG NQTIFSGGIT DSTNISSGGQ 
181:	QRVSSGGVAS NTTINSSGAQ NILSEEGAIS THISSGGNQY ISAGANATET IVNSGGFQRV 
241:	NSGAVATGTV LSGGTQNVSS GGSAISTSVY NSGVQTVFAG ATVTDTTVNS GGNQNISSGG 
301:	IVSETTVNVS GTQNIYSGGS ALSANIKGSQ IVNSEGTAIN TLVSDGGYQH IRNGGIASGT 
361:	IVNQSGYVNI SSGGYAESTI INSGGTLRVL SDGYARGTIL NNSGRENVSN GGVSYNAMIN 
421:	TGGNQYIYSD GEATAAIVNT SGFQRINSGG TAPVQNSVVV TRTVSSAAKP FDAEVYSGGK 
481:	QTVYLWRGIW YSNFLTAVWS MFPGTASGAN VNLSGRLNAF AGNVVGTILN QEGRQYVYSG 
541:	ATATSTVGNN EGREYVLSGG ITDGTVLNSG GLQAVSSGGK ASATVINEGG AQFVYDGGQV 
601:	TGTNIKNGGT IRVDSGASAL NIALSSGGNL FTSTGATLPE LTTMAALSVS QNHASNIVLE 
661:	NGGLLRVTSG GTATDTTVNS AGRLRIDDGG TINGTTTINA DGIVAGTNIQ NDGNFILNLA 
721:	ENYDFETELS GSGVLVKDNT GIMTYAGTLT QAQGVNVKNG GIIFDSAVVN ADMAVNQNAY 
781:	INISDQATIN GSVNNNGSIV INNSIINGNI TNDADLSFGT AKLLSATVNG SLVNNKNIIL 
841:	NPTKESAGNT LTVSNYTGTP GSVISLGGVL EGDNSLTDRL VVKGNTSGQS DIVYVNEDGS 
901:	GGQTRDGINI ISVEGNSDAE FSLKNRVVAG AYDYTLQKGN ESGTDNKGWY LTSHLPTSDT 
961:	RQYRPENGSY ATNMALANSL FLMDLNERKQ FRAMSDNTQP ESASVWMKIT GGISSGKLND 
1021:	GQNKTTTNQF INQLGGDIYK FHAEQLGDFT LGIMGGYANA KGKTINYTSN KAARNTLDGY 
1081:	SVGVYGTWYQ NGENATGLFA ETWMQYNWFN ASVKGDGLEE EKYNLNGLTA SAGGGYNLNV 
1141:	HTWTSPEGIT GEFWLQPHLQ AVWMGVTPDT HQEDNGTVVQ GAGKNNIQTK AGIRASWKVK 
1201:	STLDKDTGRR FRPYIEANWI HNTHEFGVKM SDDSQLLSGS RNQGEIKTGI EGVITQNLSV 
1261:	NGGVAYQAGG HGSNAISGAL GIKYSF