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1.B.12.3.1
Autoexporter of IgA protease

Accession Number:P09790
Protein Name:IgA
Length:1532
Molecular Weight:168976.00
Species:Neisseria gonorrhoeae [485]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Protease, IgA

Cross database links:

Pfam: PF03797    PF02395    PF03212   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0005576 C:extracellular region
GO:0016021 C:integral to membrane
GO:0042597 C:periplasmic space
GO:0005886 C:plasma membrane
GO:0004252 F:serine-type endopeptidase activity
GO:0006508 P:proteolysis

References (3)

[1] “Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease.”  Pohlner J.et.al.   3027577
[2] “Mosaic-like organization of IgA protease genes in Neisseria gonorrhoeae generated by horizontal genetic exchange in vivo.”  Halter R.et.al.   2511009
[3] “Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.”  Bachovchin W.W.et.al.   2105953

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKAKRFKINA ISLSIFLAYA LTPYSEAALV RDDVDYQIFR DFAENKGKFF VGATDLSVKN 
61:	KRGQNIGNAL SNVPMIDFSV ADVNKRIATV VDPQYAVSVK HAKAEVHTFY YGQYNGHNDV 
121:	ADKENEYRVV EQNNYEPHKA WGASNLGRLE DYNMARFNKF VTEVAPIAPT DAGGGLDTYK 
181:	DKNRFSSFVR IGAGRQLVYE KGVYHQEGNE KGYDLRDLSQ AYRYAIAGTP YKDINIDQTM 
241:	NTEGLIGFGN HNKQYSAEEL KQALSQDALT NYGVLGDSGS PLFAFDKQKN QWVFLGTYDY 
301:	WAGYGKKSWQ EWNIYKKEFA DKIKQHDNAG TVKGNGEHHW KTTGTNSHIG STAVRLANNE 
361:	GDANNGQNVT FEDNGTLVLN QNINQGAGGL FFKGDYTVKG ANNDITWLGA GIDVADGKKV 
421:	VWQVKNPNGD RLAKIGKGTL EINGTGVNQG QLKVGDGTVI LNQKADADKK VQAFSQVGIV 
481:	SGRGTLVLNS SNQINPDNLY FGFRGGRLDA NGNDLTFEHI RNVDEGARIV NHNTDHASTI 
541:	TLTGKSLITN PNSLSVHSIQ NDYDEDDYSY YYRPRRPIPQ GKDLYYKNYR YYALKSGGRL 
601:	NAPMPENGVA ENNDWIFMGY TQEEARKNAM NHKNNRRIGD FGGFFDEENG KGHNGALNLN 
661:	FNGKSAQKRF LLTGGANLNG KISVTQGNVL LSGRPTPHAR DFVNKSSARK DAHFSKNNEV 
721:	VFEDDWINRT FKAAEIAVNQ SASFSSGRNV SDITANITAT DNAKVNLGYK NGDEVCVRSD 
781:	YTGYVTCNTG NLSDKALNSF DATRINGNVN LNQNAALVLG KAALWGKIQG QGNSRVSLNQ 
841:	HSKWHLTGDS QVHNLSLADS HIHLNNASDA QSANKYHTIK INHLSGNGHF HYLTDLAKNL 
901:	GDKVLVKESA SGHYQLHVQN KTGEPNQEGL DLFDASSVQD RSRLFVSLAN HYVDLGALRY 
961:	TIKTENGITR LYNPYAGNGR PVKPAPSPAA NTASQAQKAT QTDGAQIAKP QNIVVAPPSP 
1021:	QANQAEEALR QQAKAEQVKR QQAAEAEKVA RQKDEEAKRK AAEIARQQEE ARKAAELAAK 
1081:	QKAEAERKAR ELARQKAEEA SHQANAKPKR RRRRAILPRP PAPVFSLDDY DAKDNSESSI 
1141:	GNLARVIPRM GRELINDYEE IPLEELEDEA EEERRQATQF HSKSRNRRAI SSEPSSDEDA 
1201:	SESVSTSDKH PQDNTELHEK VETAGLQPRA AQPRTQAAAQ ADAVSTNTNS ALSDAMASTQ 
1261:	SILLDTGAYL TRHIAQKSRA DAEKNSVWMS NTGYGRDYAS AQYRRFSSKR TQTQIGIDRS 
1321:	LSENMQIGGV LTYSDSQHTF DQAGGKNTFV QANLYGKYYL NDAWYVAGDI GAGSLRSRLQ 
1381:	TQQKANFNRT SIQTGLTLGN TLKINQFEIV PSAGIRYSRL SSADYKLGDD SVKVSSMAVK 
1441:	TLTAGLDFAY RFKVGNLTVK PLLSAAYFAN YGKGGVNVGG KSFAYKADNQ QQYSAGVALL 
1501:	YRNVTLNVNG SITKGKQLEK QKSGQIKIQI RF