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1.B.12.4.1
Autoexporter of EPEC-secreted protein C

Accession Number:Q9EZE7
Protein Name:Serine protease espC
Length:1305
Molecular Weight:140782.00
Species: [574521]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Protein virulence factor

Cross database links:

HEGENOM: HBG467630
RefSeq: YP_002330403.1   
Entrez Gene ID: 7062557   
Pfam: PF03797    PF02395   
KEGG: ecg:E2348C_2915   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0005576 C:extracellular region
GO:0016021 C:integral to membrane
GO:0042597 C:periplasmic space
GO:0005886 C:plasma membrane
GO:0004252 F:serine-type endopeptidase activity
GO:0009405 P:pathogenesis
GO:0006508 P:proteolysis

References (5)

[1] “Characterization of EspC, a 110-kilodalton protein secreted by enteropathogenic Escherichia coli which is homologous to members of the immunoglobulin A protease-like family of secreted proteins.”  Stein M.et.al.   8932311
[2] “EspC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin.”  Mellies J.L.et.al.   11119520
[3] “Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69.”  Iguchi A.et.al.   18952797
[4] “Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells.”  Kenny B.et.al.   7644526
[5] “The serine protease motif of EspC from enteropathogenic Escherichia coli produces epithelial damage by a mechanism different from that of Pet toxin from enteroaggregative E. coli.”  Navarro-Garcia F.et.al.   15155671

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNKIYALKYC HATGGLIAVS ELASRVMKKA ARGSLLALFN LSLYGAFLSA SQAAQLNIDN 
61:	VWARDYLDLA QNKGVFKAGA TNVSIQLKNG QTFNFPNVPI PDFSPASNKG ATTSIGGAYS 
121:	VTATHNGTTH HAISTQNWGQ SSYKYIDRMT NGDFAVTRLD KFVVETTGVK NSVDFSLNSH 
181:	DALERYGVEI NGEKKIIGFR VGAGTTYTVQ NGNTYSTGQV YNPLLLSASM FQLNWDNKRP 
241:	YNNTTPFYNE TTGGDSGSGF YLYDNVKKEW VMLGTLFGIA SSGADVWSIL NQYDENTVNG 
301:	LKNKFTQKVQ LNNNTMSLNS DSFTLAGNNT AVEKNNNNYK DLSFSGGGSI NFDNDVNIGS 
361:	GGLIFDAGHH YTVTGNNKTF KGAGLDIGDN TTVDWNVKGV VGDNLHKIGA GTLNVNVSQG 
421:	NNLKTGDGLV VLNSANAFDN IYMASGHGVV KINHSAALNQ NNDYRGIFFT ENGGTLDLNG 
481:	YDQSFNKIAA TDIGALITNS AVQKAVLSVN NQSNYMYHGS VSGNTEINHQ FDTQKNNSRL 
541:	ILDGNVDITN DINIKNSQLT MQGHATSHAV FREGGVTCML PGVICEKDYV SGIQQQENSA 
601:	NKNNNTDYKT NNQVSSFEQP DWENRLFKFK TLNLINSDFI VGRNAIVVGD ISANNSTLSL 
661:	SGKDTKVHID MYDGKNITGD GFGFRQDIKD GVSVSPESSS YFGNVTLNNH SLLDIGNKFT 
721:	GGIEAYDSSV SVTSQNAVFD RVGSFVNSSL TLEKGAKLTA QGGIFSTGAV DVKENASLIL 
781:	TGTPSAQKQE YYSPVISTTE GINLGDKASL SVKNMGYLSS DIHAGTTAAT INLGDGDAET 
841:	DSPLFSSLMK GYNAVLSGNI TGEQSTVNMN NALWYSDGNS TIGTLKSTGG RVELGGGKDF 
901:	ATLRVKELNA NNATFLMHTN NSQADQLNVT NKLLGSNNTV LVDFLNKPAS EMNVTLITAP 
961:	KGSDEKTFTA GTQQIGFSNV TPVISTEKTD DATKWMLTGY QTVSDAGASK TATDFMASGY 
1021:	KSFLTEVNNL NKRMGDLRDT QGDAGVWARI MNGTGSADGG YSDNYTHVQI GADRKHELDG 
1081:	VDLFTGALLT YTDSNASSHA FSGKTKSVGG GLYASALFDS GAYFDLIGKY LHHDNQYTAS 
1141:	FASLGTKDYS SHSWYAGAEV GYRYHLSEES WVEPQMELVY GSVSGKSFSW EDRGMALSMK 
1201:	DKDYNPLIGR TGVDVGRTFS GDDWKITARA GLGYQFDLLA NGETVLRDAS GEKRFEGEKD 
1261:	SRMLMNVGMN AEIKDNMRFG LELEKSAFGK YNVDNAINAN FRYSF