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1.B.12.4.5
Autotransporter-1, Pic (serine protease;1372 aas) (Henderson et al., 1999).

Accession Number:Q7BS42
Protein Name:Serine protease pic autotransporter
Length:1372
Molecular Weight:146454.00
Species:Escherichia coli O44:H18 (strain 042 / EAEC) [216592]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Serine protease, Pic

Cross database links:

Pfam: PF03797    PF02395   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0005576 C:extracellular region
GO:0042597 C:periplasmic space
GO:0005886 C:plasma membrane
GO:0004252 F:serine-type endopeptidase activity
GO:0009405 P:pathogenesis
GO:0006508 P:proteolysis

References (2)

[1] “Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli.”  Henderson I.R.et.al.   10531204
[2] “Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.”  Chaudhuri R.R.et.al.   20098708

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKVYSLKYC PVTGGLIAVS ELARRVIKKT CRRLTHILLA GIPAICLCYS QISQAGIVRS 
61:	DIAYQIYRDF AENKGLFVPG ANDIPVYDKD GKLVGRLGKA PMADFSSVSS NGVATLVSPQ 
121:	YIVSVKHNGG YRSVSFGNGK NTYSLVDRNN HPSIDFHAPR LNKLVTEVIP SAVTSEGTKA 
181:	NAYKYTERYT AFYRVGSGTQ YTKDKDGNLV KVAGGYAFKT GGTTGVPLIS DATIVSNPGQ 
241:	TYNPVNGPLP DYGAPGDSGS PLFAYDKQQK KWVIVAVLRA YAGINGATNW WNVIPTDYLN 
301:	QVMQDDFDAP VDFVSGLGPL NWTYDKTSGT GTLSQGSKNW TMHGQKDNDL NAGKNLVFSG 
361:	QNGAIILKDS VTQGAGYLEF KDSYTVSAES GKTWTGAGII TDKGTNVTWK VNGVAGDNLH 
421:	KLGEGTLTIN GTGVNPGGLK TGDGIVVLNQ QADTAGNIQA FSSVNLASGR PTVVLGDARQ 
481:	VNPDNISWGY RGGKLDLNGN AVTFTRLQAA DYGAVITNNA QQKSQLLLDL KAQDTNVSEP 
541:	TIGNISPFGG TGTPGNLYSM ILNSQTRFYI LKSASYGNTL WGNSLNDPAQ WEFVGMDKNK 
601:	AVQTVKDRIL AGRAKQPVIF HGQLTGNMDV AIPQVPGGRK VIFDGSVNLP EGTLSQDSGT 
661:	LIFQGHPVIH ASISGSAPVS LNQKDWENRQ FTMKTLSLKD ADFHLSRNAS LNSDIKSDNS 
721:	HITLGSDRAF VDKNDGTGNY VIPEEGTSVP DTVNDRSQYE GNITLNHNSA LDIGSRFTGG 
781:	IDAYDSAVSI TSPDVLLTAP GAFAGSSLTV HDGGHLTALN GLFSDGHIQA GKNGKITLSG 
841:	TPVKDTANQY APAVYLTDGY DLTGDNAALE ITRGAHASGD IHASAASTVT IGSDTPAELA 
901:	SAETAASAFA GSLLEGYNAA FNGAITGGRA DVSMHNALWT LGGDSAIHSL TVRNSRISSE 
961:	GDRTFRTLTV NKLDATGSDF VLRTDLKNAD KINVTEKATG SDNSLNVSFM NNPAQGQALN 
1021:	IPLVTAPAGT SAEMFKAGTR VTGFSRVTPT LHVDTSGGNT KWILDGFKAE ADKAAAAKAD 
1081:	SFMNAGYKNF MTEVNNLNKR MGDLRDTNGD AGAWARIMSG AGSADGGYSD NYTHVQVGFD 
1141:	KKHELDGVDL FTGVTMTYTD SSADSHAFSG KTKSVGGGLY ASALFESGAY IDLIGKYIHH 
1201:	DNDYTGNFAS LGTKHYNTHS WYAGAETGYR YHLTEDTFIE PQAELVYGAV SGKTFRWKDG 
1261:	DMDLSMKNRD FSPLVGRTGV ELGKTFSGKD WSVTARAGTS WQFDLLNNGE TVLRDASGEK 
1321:	RIKGEKDSRM LFNVGMNAQI KDNMRFGLEF EKSAFGKYNV DNAVNANFRY MF