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1.B.12.4.6
Autotransporter-1, Sat (Serine protease; 1295 aas) (Guyer et al., 2000).

Accession Number:Q8FDW4
Protein Name:Serine protease sat autotransporter
Length:1295
Molecular Weight:140043.00
Species:Escherichia coli O6 [217992]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Serine protease, Sat

Cross database links:

HEGENOM: HBG467630
Entrez Gene ID: 1039573   
Pfam: PF03797    PF02395   
KEGG: ecc:c3619   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0005576 C:extracellular region
GO:0016021 C:integral to membrane
GO:0042597 C:periplasmic space
GO:0005886 C:plasma membrane
GO:0004252 F:serine-type endopeptidase activity
GO:0009405 P:pathogenesis
GO:0006508 P:proteolysis

References (4)

[1] “Identification of sat, an autotransporter toxin produced by uropathogenic Escherichia coli.”  Guyer D.M.et.al.   11029690
[2] “Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917.”  Grozdanov L.et.al.   15292145
[3] “Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.”  Welch R.A.et.al.   12471157
[4] “Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells.”  Guyer D.M.et.al.   12117966

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKIYSLKYS AATGGLIAVS ELAKRVSGKT NRKLVATMLS LAVAGTVNAA NIDISNVWAR 
61:	DYLDLAQNKG IFQPGATDVT ITLKNGDKFS FHNLSIPDFS GAAASGAATA IGGSYSVTVA 
121:	HNKKNPQAAE TQVYAQSSYR VVDRRNSNDF EIQRLNKFVV ETVGATPAET NPTTYSDALE 
181:	RYGIVTSDGS KKIIGFRAGS GGTSFINGES KISTNSAYSH DLLSASLFEV TQWDSYGMMI 
241:	YKNDKTFRNL EIFGDSGSGA YLYDNKLEKW VLVGTTHGIA SVNGDQLTWI TKYNDKLVSE 
301:	LKDTYSHKIN LNGNNVTIKN TDITLHQNNA DTTGTQEKIT KDKDIVFTNG GDVLFKDNLD 
361:	FGSGGIIFDE GHEYNINGQG FTFKGAGIDI GKESIVNWNA LYSSDDVLHK IGPGTLNVQK 
421:	KQGANIKIGE GNVILNEEGT FNNIYLASGN GKVILNKDNS LGNDQYAGIF FTKRGGTLDL 
481:	NGHNQTFTRI AATDDGTTIT NSDTTKEAVL AINNEDSYIY HGNINGNIKL THNINSQDKK 
541:	TNAKLILDGS VNTKNDVEVS NASLTMQGHA TEHAIFRSSA NHCSLVFLCG TDWVTVLKET 
601:	ESSYNKKFNS DYKSNNQQTS FDQPDWKTGV FKFDTLHLNN ADFSISRNAN VEGNISANKS 
661:	AITIGDKNVY IDNLAGKNIT NNGFDFKQTI STNLSIGETK FTGGITAHNS QIAIGDQAVV 
721:	TLNGATFLDN TPISIDKGAK VIAQNSMFTT KGIDISGELT MMGIPEQNSK TVTPGLHYAA 
781:	DGFRLSGGNA NFIARNMASV TGNIYADDAA TITLGQPETE TPTISSAYQA WAETLLYGFD 
841:	TAYRGAITAP KATVSMNNAI WHLNSQSSIN RLETKDSMVR FTGDNGKFTT LTVNNLTIDD 
901:	SAFVLRANLA QADQLVVNKS LSGKNNLLLV DFIEKNGNSN GLNIDLVSAP KGTAVDVFKA 
961:	TTRSIGFSDV TPVIEQKNDT DKATWTLIGY KSVANADAAK KATLLMSGGY KAFLAEVNNL 
1021:	NKRMGDLRDI NGESGAWARI ISGTGSAGGG FSDNYTHVQV GADNKHELDG LDLFTGVTMT 
1081:	YTDSHAGSDA FSGETKSVGA GLYASAMFES GAYIDLIGKY VHHDNEYTAT FAGLGTRDYS 
1141:	SHSWYAGAEV GYRYHVTDSA WIEPQAELVY GAVSGKQFSW KDQGMNLTMK DKDFNPLIGR 
1201:	TGVDVGKSFS GKDWKVTARA GLGYQFDLFA NGETVLRDAS GEKRIKGEKD GRMLMNVGLN 
1261:	AEIRDNLRFG LEFEKSAFGK YNVDNAINAN FRYSF