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1.B.12.6.1
Autoexporter of vacuolating cytotoxin, VacA or Vac2, of 1287 aas.

Accession Number:Q48245
Protein Name:VAC2 aka VacA
Length:1287
Molecular Weight:139041.00
Species:Helicobacter pylori (Campylobacter pylori) [210]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Cytotoxin, VacA

Cross database links:

DIP: DIP-46228N
Pfam: PF02691   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0005576 C:extracellular region
GO:0016021 C:integral to membrane
GO:0042597 C:periplasmic space
GO:0005886 C:plasma membrane
GO:0009405 P:pathogenesis

References (2)

[1] “Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.”  Cover T.L.et.al.   8144644
[2] “Purification and characterization of the vacuolating toxin from Helicobacter pylori.”  Cover T.L.et.al.   1587837
Structure:
1SEW   2QV3     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT GTAVGTVSGL 
61:	LGWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL YKSLLSSKID GGWDWGNAAT 
121:	HYWIKGGQWN KLEVDMKDAV GTYKLSGLRN FTGGDLDVNM QKATLRLGQF NGNSFTSYKD 
181:	SADRTTRVDF NAKNILIDNF LEINNRVGSG AGRKASSTVL TLQASEGITS SKNAEISLYD 
241:	GATLNLASNS VKLNGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVNFNHL TVGDHNAAQA 
301:	GIIASNKTHI GTLDLWQSAG LNIIAPPEGG YKDKPNNTPS QSGAKNDKQE SSQNNSNTQV 
361:	INPPNSTQKT EVQPTQVIDG PFAGGKDTVV NIDRINTKAD GTIKVGGFKA SLTTNAAHLN 
421:	IGKGGVNLSN QASGRTLLVE NLTGNITVDG PLRVNNQVGG YALAGSSANF EFKAGVDTKN 
481:	GTATFNNDIS LGRFVNLKVD AHTANFKGID TGNGGFNTLD FSGVTNKVNI NKLITASTNV 
541:	AVKNFNINEL IVKTNGVSVG EYTHFSEDIG SQSRINTVRL ETGTRSIFSG GVKFKSGEKL 
601:	VIDEFYYSPW NYFDARNIKN VEITRKFASS TPENPWGTSK LMFNNLTLGQ NAVMDYSQFS 
661:	NLTIQGDFIN NQGTINYLVR GGKVATLNVG NAAAMMFNND IDSATGFYKP LIKINSAQDL 
721:	IKNTEHVLLK AKIIGYGNVS TGTNGISNVN LEEQFKERLA LYNNNNRMDT CVVRNTDDIK 
781:	ACGMAIGNQS MVNNPDNYKY LIGKAWKNIG ISKTANGSKI SVYYLGNSTP TENGGNTTNL 
841:	PTNTTNNARF ASYALIKNAP FAHSATPNLV AINQHDFGTI ESVFELANRS KDIDTLYANS 
901:	GAQGRDLLQT LLIDSHDAGY ARTMIDATSA NEITKQLNTA TTTLNNIASL EHKTSSLQTL 
961:	SLSNAMILNS RLVNLSRRHT NNIDSFAKRL QALKDQRFAS LESAAEVLYQ FAPKYEKPTN 
1021:	VWANAIGGAS LNNGGNASLY GTSAGVDAYL NGQVEAIVGG FGSYGYSSFN NQANSLNSGA 
1081:	NNTNFGVYSR IFANQHEFDF EAQGALGSDQ SSLNFKSALL RDLNQSYNYL AYSAATRASY 
1141:	GYDFAFFRNA LVLKPSVGVS YNHLGSTNFK SNSTNKVALS NGSSSQHLFN ASANVEARYY 
1201:	YGDTSYFYMN AGVLQEFANF GSSNAVSLNT FKVNATRNPL NTHARVMMGG ELKLAKEVFL 
1261:	NLGVVYLHNL ISNIGHFASN LGMRYSF