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1.B.12.8.3
Autotransporter-1, TibA (989 aas; an Adhesin/Invasin associated with some enterotoxigenic E. coli) (Lindenthal and Elsinghorst et al., 1999; Klemm et al. 2006Klemm et al. 2006).

Accession Number:Q9XD84
Protein Name:Adhesin/invasin tibA autotransporter
Length:989
Molecular Weight:101112.00
Species:Escherichia coli [562]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Adhesin, TibA

Cross database links:

Pfam: PF03797    PF03212   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0009986 C:cell surface
GO:0005576 C:extracellular region
GO:0042597 C:periplasmic space
GO:0005886 C:plasma membrane
GO:0007155 P:cell adhesion
GO:0009405 P:pathogenesis

References (4)

[1] “Identification of a glycoprotein produced by enterotoxigenic Escherichia coli.”  Lindenthal C.et.al.   10417177
[2] “Epithelial cell invasion and adherence directed by the enterotoxigenic Escherichia coli tib locus is associated with a 104-kilodalton outer membrane protein.”  Elsinghorst E.A.et.al.   8039917
[3] “Enterotoxigenic Escherichia coli TibA glycoprotein adheres to human intestine epithelial cells.”  Lindenthal C.et.al.   11119488
[4] “The TibA adhesin/invasin from enterotoxigenic Escherichia coli is self recognizing and induces bacterial aggregation and biofilm formation.”  Sherlock O.et.al.   15784535
Structure:
4Q1Q     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNKVYNTVWN ESTGTWVVTS ELTRKGGLRP RQIKRTVLAG LIAGLLMPSM PALAAAYDNQ 
61:	TIGRGETSKS MHLSAGDTAK NTTINSGGKQ YVSSGGSATS TTINIGGVQH VSSGGSATSS 
121:	TINSGGHQHV SSGGSATNTT VNNGGRQTVF SGGSAMGTII NSGGDQYVIS GGSATSASVT 
181:	SGARQFVSSG GIVKATSVNS GGRQYVRDGG SATDTVLNNT GRQFVSSGGS AAKTTINSGG 
241:	GMYLYGGSAT GTSIYNGGRQ YVSSGGSATN TTVYSGGRQH VYIDGNVTET TITSGGMLQV 
301:	EAGGSASKVI QNSGGAVITN TSAAVSGTND NGSFSIAGGS AVNMLLENGG YLTVFDGHQA 
361:	SDTMVGSDGT LDVRSGGVLY GTTTLTDKGA LVGDVVTNEG NLYYLNNSTA TFTGTLTGTG 
421:	TLTQEGGNTR FSGLLSQDGG IFLQSGGAMT MDALQAKANV TTQSGTTLTL DNGTILTGNV 
481:	AGDSTGAGDM AVKGASVWHL DGDSTVGALT LDNGTVDFRP STTTRMTPAF QAVSLALGSL 
541:	SGSGTFQMNT DIASHTGDML NVAGNASGNF VLDIKNTGLE PVSAGAPLQV VQTGGGDAAF 
601:	TLKGGKVDAG TWEYGLSKEN TNWYLKADTP PPVTPPTNPD ADNPDAGNPD AGNPDAGNPD 
661:	AGNPDAGKPG TGKPDAGTSS SPVRRTTKSV DAVLGMATAP AYVFNSELDN LRFRHGDVMQ 
721:	NTRAPGGVWG RYTGSDNRIS GGASSGYTLT QNGFETGADM VFDLSDSSLA VGTFFSYSDN 
781:	SIKHARGGKS NVDSSGGGLY ATWFDNDGYY VDGVLKYNRF NNELRTWMSD GTAVKGDYSQ 
841:	NGFGGSLEAG RTFSLNENAW AQPYVRTTAF RADKKEIRLN NGMKASIGAT KSLQAEAGLK 
901:	LGMTLDVAGK EVKPYLSAAV SHEFSDNNKV RINDTYDFRN DISGTTGKYG LGVNAQLTPN 
961:	AGVWAEARYE NGKQTESPIT GGVGFRINF