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1.B.14.1.22
FepA ferri-enterobactin (also Colicins B and D) receptor for the 37 aas disulfide-containing K+ channel toxin, BgK (Braud et al., 2004). Functions by a "ball and chain" mechanism; The transport process involves expulsion of the N-terminal globular domain from the C-terminal beta-barrel (Ma et al. 2007).

Accession Number:P05825
Protein Name:FepA aka FEP aka FEUB aka B0584
Length:746
Molecular Weight:82107.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Fe3+-enterobactin, Colicin B, Colicin D, K+

Cross database links:

Genevestigator: P05825 P05825
EchoBASE: EB0289 EB0289
EcoGene: EG10293 EG10293
eggNOG: COG4771 COG4771
HEGENOM: HBG464298 HBG464298
DIP: DIP-9592N DIP-9592N
RefSeq: AP_001230.1    NP_415116.1   
Entrez Gene ID: 945193   
Pfam: PF07715    PF00593   
BioCyc: EcoCyc:EG10293-MONOMER    ECOL168927:B0584-MONOMER   
KEGG: ecj:JW5086    eco:b0584    ecj:JW5086    eco:b0584   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005506 F:iron ion binding
GO:0004872 F:receptor activity
GO:0015343 F:siderophore-iron transmembrane transporter ...
GO:0006826 P:iron ion transport
GO:0015891 P:siderophore transport
GO:0015343 F:siderophore-iron transmembrane transporter activity

References (16)

[1] “Nucleotide sequence of the gene for the ferrienterochelin receptor FepA in Escherichia coli. Homology among outer membrane receptors that interact with TonB.”  Lundrigan M.D.et.al.   3015941
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Transcriptional mapping and nucleotide sequence of the Escherichia coli fepA-fes enterobactin region. Identification of a unique iron-regulated bidirectional promoter.”  Pettis G.S.et.al.   2974033
[6] “The Escherichia coli enterobactin biosynthesis gene, entD: nucleotide sequence and membrane localization of its protein product.”  Armstrong S.K.et.al.   2526281
[7] “Molecular analysis of the Escherichia coli ferric enterobactin receptor FepA.”  Armstrong S.K.et.al.   2201687
[8] “Crystal structure of the outer membrane active transporter FepA from Escherichia coli.”  Buchanan S.K.et.al.   9886293
[9] “Nucleotide sequence of the gene for the ferrienterochelin receptor FepA in Escherichia coli. Homology among outer membrane receptors that interact with TonB.”  Lundrigan M.D.et.al.   3015941
[10] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[11] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[12] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[13] “Transcriptional mapping and nucleotide sequence of the Escherichia coli fepA-fes enterobactin region. Identification of a unique iron-regulated bidirectional promoter.”  Pettis G.S.et.al.   2974033
[14] “The Escherichia coli enterobactin biosynthesis gene, entD: nucleotide sequence and membrane localization of its protein product.”  Armstrong S.K.et.al.   2526281
[15] “Molecular analysis of the Escherichia coli ferric enterobactin receptor FepA.”  Armstrong S.K.et.al.   2201687
[16] “Crystal structure of the outer membrane active transporter FepA from Escherichia coli.”  Buchanan S.K.et.al.   9886293
Structure:
1FEP     

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FASTA formatted sequence
1:	MNKKIHSLAL LVNLGIYGVA QAQEPTDTPV SHDDTIVVTA AEQNLQAPGV STITADEIRK 
61:	NPVARDVSKI IRTMPGVNLT GNSTSGQRGN NRQIDIRGMG PENTLILIDG KPVSSRNSVR 
121:	QGWRGERDTR GDTSWVPPEM IERIEVLRGP AAARYGNGAA GGVVNIITKK GSGEWHGSWD 
181:	AYFNAPEHKE EGATKRTNFS LTGPLGDEFS FRLYGNLDKT QADAWDINQG HQSARAGTYA 
241:	TTLPAGREGV INKDINGVVR WDFAPLQSLE LEAGYSRQGN LYAGDTQNTN SDSYTRSKYG 
301:	DETNRLYRQN YALTWNGGWD NGVTTSNWVQ YEHTRNSRIP EGLAGGTEGK FNEKATQDFV 
361:	DIDLDDVMLH SEVNLPIDFL VNQTLTLGTE WNQQRMKDLS SNTQALTGTN TGGAIDGVST 
421:	TDRSPYSKAE IFSLFAENNM ELTDSTIVTP GLRFDHHSIV GNNWSPALNI SQGLGDDFTL 
481:	KMGIARAYKA PSLYQTNPNY ILYSKGQGCY ASAGGCYLQG NDDLKAETSI NKEIGLEFKR 
541:	DGWLAGVTWF RNDYRNKIEA GYVAVGQNAV GTDLYQWDNV PKAVVEGLEG SLNVPVSETV 
601:	MWTNNITYML KSENKTTGDR LSIIPEYTLN STLSWQARED LSMQTTFTWY GKQQPKKYNY 
661:	KGQPAVGPET KEISPYSIVG LSATWDVTKN VSLTGGVDNL FDKRLWRAGN AQTTGDLAGA 
721:	NYIAGAGAYT YNEPGRTWYM SVNTHF