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1.B.14.1.4
CirA Fe3+-catecholate receptor. Serves as the receptor for the TonB- and proton-dependent uptake of the E. coli bacteriocin, Microcin L (MccL) (Morin et al., 2011). CirA is also the translocator for colicin Ia (Jakes and Finkelstein, 2010). Plays roles in cefiderocol and ceftazidime resistance (Ito et al. 2018).

Accession Number:P17315
Protein Name:CirA aka CIR aka FEUA aka B2155
Length:663
Molecular Weight:73896.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate Fe3+-catecholate

Cross database links:

Genevestigator: P17315
EchoBASE: EB0153
EcoGene: EG10155
eggNOG: COG4771
HEGENOM: HBG464298
DIP: DIP-9282N
RefSeq: AP_002752.1    NP_416660.1   
Entrez Gene ID: 949042   
Pfam: PF07715    PF00593   
Drugbank: Drugbank Link   
BioCyc: EcoCyc:EG10155-MONOMER    ECOL168927:B2155-MONOMER   
KEGG: ecj:JW2142    eco:b2155   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0004872 F:receptor activity
GO:0005215 F:transporter activity
GO:0006826 P:iron ion transport

References (6)

[1] “Evolutionary relationship between the TonB-dependent outer membrane transport proteins: nucleotide and amino acid sequences of the Escherichia coli colicin I receptor gene.”  Nau C.D.et.al.   2644220
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Cloning and promoter identification of the iron-regulated cir gene of Escherichia coli.”  Griggs D.W.et.al.   3316180
[5] “The lysP gene encodes the lysine-specific permease.”  Steffes C.et.al.   1315732
[6] “Activation of expression of the Escherichia coli cir gene by an iron-independent regulatory mechanism involving cyclic AMP-cyclic AMP receptor protein complex.”  Griggs D.W.et.al.   2160948
Structure:
2HDF   2HDI     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFRLNPFVRV GLCLSAISCA WPVLAVDDDG ETMVVTASSV EQNLKDAPAS ISVITQEDLQ 
61:	RKPVQNLKDV LKEVPGVQLT NEGDNRKGVS IRGLDSSYTL ILVDGKRVNS RNAVFRHNDF 
121:	DLNWIPVDSI ERIEVVRGPM SSLYGSDALG GVVNIITKKI GQKWSGTVTV DTTIQEHRDR 
181:	GDTYNGQFFT SGPLIDGVLG MKAYGSLAKR EKDDPQNSTT TDTGETPRIE GFSSRDGNVE 
241:	FAWTPNQNHD FTAGYGFDRQ DRDSDSLDKN RLERQNYSVS HNGRWDYGTS ELKYYGEKVE 
301:	NKNPGNSSPI TSESNTVDGK YTLPLTAINQ FLTVGGEWRH DKLSDAVNLT GGTSSKTSAS 
361:	QYALFVEDEW RIFEPLALTT GVRMDDHETY GEHWSPRAYL VYNATDTVTV KGGWATAFKA 
421:	PSLLQLSPDW TSNSCRGACK IVGSPDLKPE TSESWELGLY YMGEEGWLEG VESSVTVFRN 
481:	DVKDRISISR TSDVNAAPGY QNFVGFETGA NGRRIPVFSY YNVNKARIQG VETELKIPFN 
541:	DEWKLSINYT YNDGRDVSNG ENKPLSDLPF HTANGTLDWK PLALEDWSFY VSGHYTGQKR 
601:	ADSATAKTPG GYTIWNTGAA WQVTKDVKLR AGVLNLGDKD LSRDDYSYNE DGRRYFMAVD 
661:	YRF