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1.B.14.1.9
Ferric-catecholate siderophore (dihydroxybenzoylserine, dihydroxybenzoate) uptake receptor, Fiu or YbiL (Hantke, 1990; Curtis et al., 1988). Plays roles in cefiderocol and ceftazidime resistance (Ito et al. 2018).

Accession Number:P75780
Protein Name:Ferric iron uptake protein aka Fiu
Length:760
Molecular Weight:81960.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate Fe3+-dihydroxybenzoylserine, Fe3+-dihydroxybenzoate

Cross database links:

Genevestigator: P75780
EchoBASE: EB3101
EcoGene: EG13317
eggNOG: COG4774
HEGENOM: HBG542811
DIP: DIP-11432N
RefSeq: AP_001436.1    NP_415326.1   
Entrez Gene ID: 946246   
Pfam: PF07715    PF00593   
BioCyc: EcoCyc:G6414-MONOMER    ECOL168927:B0805-MONOMER   
KEGG: ecj:JW0790    eco:b0805   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0005506 F:iron ion binding
GO:0004872 F:receptor activity
GO:0015343 F:siderophore-iron transmembrane transporter ...
GO:0006826 P:iron ion transport
GO:0015891 P:siderophore transport

References (11)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Iron-regulated outer membrane proteins of Escherichia coli K-12 and mechanism of action of catechol-substituted cephalosporins.”  Curtis N.A.C.et.al.   3072926
[5] “Dihydroxybenzoylserine -- a siderophore for E. coli.”  Hantke K.et.al.   2139424
[6] “Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups.”  Nikaido H.et.al.   2407721
[7] “Iron content and FNR-dependent gene regulation in Escherichia coli.”  Niehaus F.et.al.   1804764
[8] “Differential fiu-lacZ fusion regulation linked to Escherichia coli colony development.”  Newman D.L.et.al.   10411720
[9] “Proteomic analysis of the Escherichia coli outer membrane.”  Molloy M.P.et.al.   10806384
[10] “The colicin G, H and X determinants encode microcins M and H47, which might utilize the catecholate siderophore receptors FepA, Cir, Fiu and IroN.”  Patzer S.I.et.al.   12949180
[11] “Parasitism of iron-siderophore receptors of Escherichia coli by the siderophore-peptide microcin E492m and its unmodified counterpart.”  Destoumieux-Garzon D.et.al.   16718603

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MENNRNFPAR QFHSLTFFAG LCIGITPVAQ ALAAEGQTNA DDTLVVEAST PSLYAPQQSA 
61:	DPKFSRPVAD TTRTMTVISE QVIKDQGATN LTDALKNVPG VGAFFAGENG NSTTGDAIYM 
121:	RGADTSNSIY IDGIRDIGSV SRDTFNTEQV EVIKGPSGTD YGRSAPTGSI NMISKQPRND 
181:	SGIDASASIG SAWFRRGTLD VNQVIGDTTA VRLNVMGEKT HDAGRDKVKN ERYGVAPSVA 
241:	FGLGTANRLY LNYLHVTQHN TPDGGIPTIG LPGYSAPSAG TAALNHSGKV DTHNFYGTDS 
301:	DYDDSTTDTA TMRFEHDIND NTTIRNTTRW SRVKQDYLMT AIMGGASNIT QPTSDVNSWT 
361:	WSRTANTKDV SNKILTNQTN LTSTFYTGSI GHDVSTGVEF TRETQTNYGV NPVTLPAVNI 
421:	YHPDSSIHPG GLTRNGANAN GQTDTFAIYA FDTLQITRDF ELNGGIRLDN YHTEYDSATA 
481:	CGGSGRGAIT CPTGVAKGSP VTTVDTAKSG NLMNWKAGAL YHLTENGNVY INYAVSQQPP 
541:	GGNNFALAQS GSGNSANRTD FKPQKANTSE IGTKWQVLDK RLLLTAALFR TDIENEVEQN 
601:	DDGTYSQYGK KRVEGYEISV AGNITPAWQV IGGYTQQKAT IKNGKDVAQD GSSSLPYTPE 
661:	HAFTLWSQYQ ATDDISVGAG ARYIGSMHKG SDGAVGTPAF TEGYWVADAK LGYRVNRNLD 
721:	FQLNVYNLFD TDYVASINKS GYRYHPGEPR TFLLTANMHF