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1.B.14.11.1
The Nickel (Ni2+) receptor (FrpB4; Hp1512) of 877 aas. Energized by the TonB/ExbBD complex (Schauer et al., 2007). Capable of binding both haem and haemoglobin but shows greater affinity for haem. The mRNA levels of frpB1 were repressed by iron and lightly modulated by haem or haemoglobin. Overexpression of the frpB1 gene supported cellular growth when haem or haemoglobin were supplied as the only iron source (Carrizo-Chávez et al. 2012).

Accession Number:Q9ZJA8
Protein Name:FrpB_4
Length:879
Molecular Weight:97573.00
Species:Helicobacter pylori J99 (Campylobacter pylori J99) [85963]
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate Ni2+

Cross database links:

eggNOG: COG1629
HEGENOM: HBG501580
RefSeq: NP_224123.1   
Entrez Gene ID: 889947   
Pfam: PF07715    PF00593   
BioCyc: HPYL85963:JHP1405-MONOMER   
KEGG: hpj:jhp1405   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0004872 F:receptor activity
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.”  Alm R.A.et.al.   9923682

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLRNQFRIVF VSCIVASSLQ AQENTHTLGK VTTKGERTFE YNNKMYIDRK ELQQRQSNQI 
61:	RDIFRTRADV NVASGGLMAQ KIYVRGIESR LLRVTIDGVA QNGNIFHHDA NTVIDPNMIK 
121:	EVEVIKGAAN ASAGPGAVAG KLSFTTIDAN DFLRKNQTYG AKAEAAFYTN FGYRMNATAA 
181:	YRGKNWDILA YYNHQNIFYY RDGNNAFRSL FHPNYDLQDP SNSEMSVGTP SEVNSVLAKI 
241:	NGYINETDSI SVSYNLTRDN STRLLRPNTT SALSKANDPG SQPAPFVIDF GKELAHTINF 
301:	NHNLSLKYKH EGGPNFNQPR VESTAFLGVR GGNYNPVVNP FAYNSNEPAN PDYIPEVKEW 
361:	CNNPDNISQC TQGAIRPSNG GYQIGYGAPN FINWQGDSDS SGGAQAGYGQ LSATMLSASA 
421:	NVYHGLVPKN PDYDMTPPNA QNPSANDWTL GNADAEGTLA RRIFLINSGV NVKVTHPISE 
481:	DYGNVFEYGM IYQNLSVFSG LDKGKNGYYK NNIDPNDPNG PGLPYRHYYT DQSSQYPQNL 
541:	NTPNPLYRNM PQNSHAIGNI IGGFVQANYN ILSNVVVGAG TRYDIYTLLD KNGRTHVTSG 
601:	FSPSATVLYN PIESIGLKVS YAYVTKGALP GDDVLMRDPT VIYQRNLRPS IGQNVEFNVD 
661:	YNSKYFNVRG AAFYQVINNF INSYGQDTSK NGGGNATAKN MSGNLPETIN VYGYEVSGNV 
721:	KYKNFLGTFS VARSWPTARG HLLADTYALA ATTGNVFILK ADYDIRRWGL TLTWLSRFVT 
781:	NMYYEGYSIY YPQYGLIKIH KPGYGVHNIF INWTPPSKKW QGLRISAVFN NILNKQYVDQ 
841:	TSVFQASADA PASDMIPKGK RMALPAPGFN ARFEVSYQF