TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.B.17.1.1









TolC outer membrane exporter of hemolysin, drugs, siderophores such as enterobactin, etc. (Bleuel et al., 2005). The 3-d structure is available (PDB#1EK9).  The Salmonella enterica subspecies Typhi homologue is the ST50 antigen (G4C2H4) used in tests for typhoid fever, and a 2.98 Å resolution structure revealed a trimer that forms an alpha-helical tunnel and a beta-barrel transmembrane channel traversing the periplasmic space and outer membrane, respectively (Guan et al. 2015).

Bacteria
Proteobacteria
TolC of E. coli
*1.B.17.1.2









PrtF outer membrane exporter of proteases
Bacteria
Proteobacteria
PrtF of Erwinia chrysanthemi
*1.B.17.1.3









The OMF, EexF (functions with ABC exporter, EexD (TC# 3.A.1.110.10) and MFP EexE (TC# 8.A.1.3.3)) (Gimmestad et al., 2006).

Bacteria
Proteobacteria
EexF of Azotobacter vinelandii (C1DS86)
*1.B.17.1.4









TolC of Sinorhizobium meliloti (affects secretion of proteins, polysaccharide, and multiple drugs (Cosme et al., 2008))

Bacteria
Proteobacteria
TolC of Sinorhizobium meliloti (Q92Q38)
*1.B.17.1.5









Putative outer membrane factor of 420 aas

Bacteria
Chlamydiae/Verrucomicrobia group
Outer membrane factor of Parachlamydia acanthamoebae
*1.B.17.1.6









Uncharacterized protein of 425 aas with an N-terminal TMS.

Bacteria
Proteobacteria
UP of Bdellovibrio exovorus
*1.B.17.1.7









Outer membrane protein of 462 aas and 1 N-terminal TMS

Bacteria
Proteobacteria
OMP of Bdellovibrio bacteriovorus
*1.B.17.2.1









CnrC outer membrane exporter of Ni2+ and Co2+.  Functions with TC# 2.A.6.1.1 and 8.A.1.2.1.

Bacteria
Proteobacteria
CnrC of Alcaligenes eutrophus
*1.B.17.2.2









CzcC outer membrane exporter of Co2+, Cd2+, Zn2+.  Functions with CzcAB (2.A.6.1.2).

Bacteria
Proteobacteria
CzcC of Alcaligenes eutrophus
*1.B.17.2.3









CyaE outer membrane exporter of cyclolysin
Bacteria
Proteobacteria
CyaE of Bordetella pertussis
*1.B.17.2.4









Outer membrane efflux protein of the OEP or OMF family

Bacteria
Proteobacteria
OEP of Myxococcus xanthus
*1.B.17.2.5









Outer membrane efflux protein

Bacteria
Firmicutes
Outer membrane efflux protein of Selenomonas sputigena
*1.B.17.2.6









Outer membrane efflux porin, Oep

Bacteria
Proteobacteria
Oep of Myxococcus xanthus
*1.B.17.2.7









Outer membrane efflux porin, Oep (OMF family)

Bacteria
Proteobacteria
Oep of Myxococcus xanthus
*1.B.17.2.8









Outer membrane efflux porin (Bhat et al. 2011).

Bacteria
Proteobacteria
Oep of Myxococcus xanthus
*1.B.17.2.9









Outer membrane efflux protein, Oep

Bacteria
Proteobacteria
Oep of Myxococcus xanthus
*1.B.17.2.10









Putative ABC-type glycolipid export outer membrane factor, HgdD, of 483 aas (Hahn et al., 2012).

Bacteria
Cyanobacteria
HgdD of Thermosynechococcus sp. NK55a.
*1.B.17.2.11









Uncharacterized OMF protein of 485 aas and 1 N-terminlal TMS.

Bacteria
Proteobacteria
UP of Bdellovibrio bacteriovorus
*1.B.17.3.1









NodT2 outer membrane exporter of lipooligosaccharides
Bacteria
Proteobacteria
NodT2 of Rhizobium leguminosarum
*1.B.17.3.2









FusA outer membrane exporter of fusaric acid
Bacteria
Proteobacteria
FusA of Burkholderia cepacia
*1.B.17.3.3









OpcM outer membrane exporter of multiple drugs
Bacteria
Proteobacteria
OpcM of Burkholderia cepacia
*1.B.17.3.4









SilC outer membrane exporter of silver ion, Ag+
Bacteria
Proteobacteria
SilC of Salmonella typhimurium
*1.B.17.3.5









CusC outer membrane exporter of copper ion, Cu+, and silver ion Ag+.  The crystal structure of CusC is known (Lei et al. 2013) providing evidnce concerning the folding mechanism giving rise to the channel.

Bacteria
Proteobacteria
CusC (YlcB) of E. coli
*1.B.17.3.6









VceC outer membrane exporter of drugs (Federici et al., 2005)
Bacteria
Proteobacteria
VceC of Vibrio cholerae (A6XV56)
*1.B.17.3.7









HI1462 outer membrane, low conductance, anion-selective exporter (selectivity is due to an arginine residue at the tunnel entrance). (Polleichtner and Anderson, 2006)
Bacteria
Proteobacteria
HI1462 of Haemophilus influenzae (P45217)
*1.B.17.3.8









Chromosomal NodTch (orthologous to 1.B.17.3.1) (478 aas) required for cell survival (Hernandez-Mendoza et al., 2007).

Bacteria
Proteobacteria
NodTch of Rhizobium etli (B3PY75)
*1.B.17.3.9









MdtP (acts with MdtO (TC# 2.A.85.6.1) and MdtN (TC# 8.A.1.1.3)) (Sulavik et al., 2001).

Bacteria
Proteobacteria
MdtP of E. coli (P32714)
*1.B.17.3.10









Outer membrane factor of 478 aas, MdtQ (YohG). Involved in resistance to puromycin, acriflavin and tetraphenylarsonium chloride (Sulavik et al. 2001).

Bacteria
Proteobacteria
MdtQ of E. coli
*1.B.17.3.11









TolC-like outer membrane factor protein, TdeA of 457 aas, required for leukotoxin and drug export (Crosby and Kachlany 2007).  Functions with the MFP, LtxD (TC# 8.A.1.3.4) and the ABC exporter (TC# 3.A.1.109.8).

Bacteria
Proteobacteria
TdeA of Aggregatibacter (Actinobacillus; Haemophilus) actinomycetemcomitans
*1.B.17.4.1









Outer membrane factor of 459 aas.  May function with an ABC exporter (A0LKG3/A0LKG4) and a membrane fusion protein (A0LKG1) (based on genomic context).

Bacteria
Proteobacteria
OMF of Syntrophobacter fumaroxidans