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1.B.17.2.2
CzcC outer membrane exporter of Co2+, Cd2+, Zn2+.  Functions with CzcAB (2.A.6.1.2).

Accession Number:P13509
Protein Name:CzcC
Length:418
Molecular Weight:44807.00
Species:Alcaligenes eutrophus (Ralstonia eutropha) [266264]
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate Co2+, Cd2+, Zn2+

Cross database links:

eggNOG: COG1538
HEGENOM: HBG691656
RefSeq: YP_145593.1    YP_145594.1    YP_581790.1    YP_581791.1   
Entrez Gene ID: 3170371    3170389    4036516    4036517   
Pfam: PF02321   
BioCyc: RMET266264:RMET_5982-MONOMER   
KEGG: rme:Rmet_5982   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0046686 P:response to cadmium ion
GO:0006810 P:transport

References (2)

[1] “Expression and nucleotide sequence of a plasmid-determined divalent cation efflux system from Alcaligenes eutrophus.”  Nies D.H.et.al.   2678100
[2] “The czc operon of Alcaligenes eutrophus CH34: from resistance mechanism to the removal of heavy metals.”  Diels L.et.al.   7766206

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRRLFLPLGL AVAFLSPNFA VAQSDTGTSM VPVFPREAAG PLTLEAALSL AAGSNFNLSA 
61:	AAKELDSTEG GIMQARVIPN PELKTLVEDT RKSTRTSTAQ MNIPIELGGK RSARINAAER 
121:	TRELAQATLA GVRGDIRAQV IESFFSVLIA QERVKLATGS ADIAARGAQA ASRRVAAGKI 
181:	SPVDETKARV EQANAELELA EATASLQSAR QALTALWGNA SPQFAEAQGN LDALPSRPAP 
241:	ELLQKELENS PLVAASRAEL DRRQALVGVE RSRQYPDLTV SLGAKRDTEA NRNMAVIGVA 
301:	IPLPIFDRNQ GNLYSAIRQA DKAQDEYLAN RISLTRNLLM ASNQLSVSRA SAQTLKQTVL 
361:	PGAEQAFNAA TIGFEAGKFN YLDVLDAQRT LFQARIRYLG VLGQTYQAAT TIDRILGR