TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.B.17.2.3
CyaE outer membrane exporter of cyclolysin

Accession Number:P11092
Protein Name:CyaE
Length:474
Molecular Weight:50205.00
Species:Bordetella pertussis [520]
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Peripheral membrane protein2
Substrate Cyclolysin

Cross database links:

HEGENOM: HBG037708
RefSeq: NP_879581.1   
Entrez Gene ID: 2664625   
Pfam: PF02321   
BioCyc: BPER257313:BP0763-MONOMER   
KEGG: bpe:BP0763   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0006810 P:transport

References (2)

[1] “Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis.”  Glaser P.et.al.   2905265
[2] “Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.”  Parkhill J.et.al.   12910271

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAAVQVRRRG RALALALWAG FALSVGGGVR ARDGLATPPA FEGQAAPAVS WPCPPPADRL 
61:	DDLALLEAID LALCHSPALR QGWARIKARS AEVGLARAPY YPSVALSAGR SAQRRSTGLG 
121:	EDGVRNNVMA VTLAWRLFDS GARSAALRAA QAQLDEAAQA YGAVLQDKLA EVVGAYYEAA 
181:	TARQALHTAV EDTEIARRSA SIAARRARAG LDSHGDVLHA QAALERARLA QAQAEGAQAR 
241:	ALAGLAQVLG VDPATPIVLA PGPLAPQRIE DRELAQWLRD ARQRHPAIKA AQAGLAAATA 
301:	QVDVARATDM PTVDLSLGHY RNSSENVSVF AGSSRSVSAS LNLRIPLFDG FARRHRIQGA 
361:	RAEVQRQEAL LDQARLATGA AVARAYADLR AARASHEASL RWLKAARAAY ESDLRRYEAG 
421:	VGGVAELLRA QSDWLSARQR HVLYAAQLRT RALALLAAAG ELGRSTIDGD PPKE