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1.B.17.3.9
MdtP (acts with MdtO (TC# 2.A.85.6.1) and MdtN (TC# 8.A.1.1.3)) (Sulavik et al., 2001).

Accession Number:P32714
Protein Name:Multidrug resistance outer membrane protein mdtP
Length:488
Molecular Weight:53453.00
Species:Escherichia coli (strain K12) [83333]
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Lipid-anchor2
Substrate small molecules

Cross database links:

Genevestigator: P32714
EchoBASE: EB1895
EcoGene: EG11952
eggNOG: COG1538
HEGENOM: HBG759011
RefSeq: AP_004581.1    NP_418504.1   
Entrez Gene ID: 948583   
Pfam: PF02321   
BioCyc: EcoCyc:EG11952-MONOMER    ECOL168927:B4080-MONOMER   
KEGG: ecj:JW4041    eco:b4080   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0008289 F:lipid binding
GO:0015559 ?:?
GO:0005515 F:protein binding
GO:0015546 F:sulfathiazole transporter activity
GO:0046677 P:response to antibiotic
GO:0015906 P:sulfathiazole transport

References (4)

[1] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.”  Blattner F.R.et.al.   8265357
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.”  Sulavik M.C.et.al.   11257026

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MINRQLSRLL LCSILGSTTL ISGCALVRKD SAPHQQLKPE QIKLADDIHL ASSGWPQAQW 
61:	WKQLNDPQLD ALIQRTLSGS HTLAEAKLRE EKAQSQADLL DAGSQLQVAA LGMLNRQRVS 
121:	ANGFLSPYSM DAPALGMDGP YYTEATVGLF AGLDLDLWGV HRSAVAAAIG AHNAALAETA 
181:	AVELSLATGV AQLYYSMQAS YQMLDLLEQT HDVIDYAVKA HQSKVAHGLE AQVPFHGARA 
241:	QILAVDKQIV AVKGQITETR ESLRALIGAG ASDMPEIRPV ALPQVQTGIP ATLSYELLAR 
301:	RPDLQAMRWY VQASLDQVDS ARALFYPSFD IKAFFGLDSI HLHTLFKKTS RQFNFIPGLK 
361:	LPLFDGGRLN ANLEGTRAAS NMMIERYNQS VLNAVRDVAV NGTRLQTLND EREMQAERVE 
421:	ATRFTQRAAE AAYQRGLTSR LQATEARLPV LAEEMSLLML DSRRVIQSIQ LMKSLGGGYQ 
481:	AGPVVEKK