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1.B.20.3.2
HMW1B outer membrane exporter, required for secretion of HMW1A and HMW2A adhesins (exhibit a twin pore dimeric structure) (Li et al., 2007) and forms a large-conductance channel (Duret et al., 2008).  The protein has a modular three domain structure: an N-terminal  membrane domain, a central periplasmic domain and a C-terminal membrane anchor domain that oligomerizes and forms a pore (Surana et al. 2006).  The periplasmic domain is required for secretion.

Accession Number:Q4QJR3
Protein Name:HMW1B
Length:545
Molecular Weight:60699.00
Species:Haemophilus influenzae (strain 86-028NP) [281310]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

eggNOG: COG2831
HEGENOM: HBG495106
RefSeq: YP_249394.1   
Entrez Gene ID: 3431234   
BioCyc: HINF281310:NTHI1984-MONOMER   
KEGG: hit:NTHI1984   

References (1)

[1] “Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20.”  Harrison A.et.al.   15968074

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNIKSRLKL SAISVLLGLA SSSLYAEEAF LVKGFQLSGA LETLSEDAQL SVAKSLSKYQ 
61:	GTQTLTNLKT AQLELQAVLD KIEPNKFDVI LPQQTITDGN IMFELVSKSA AESQVFYKAS 
121:	QGYSEENIAR SLPSLKQGKV YEDGRQWFDL REFNMAKENP LKVTRVHYEL NPKNKTSNLI 
181:	IAGFSPFGKT RSFISYDNFG AREFNYQRVS LGFVNANLTG HDDVLNLNAL TNVKAPSKSY 
241:	AVGVGYTYPF YSKHQSLSLY TSMSYADSND IDGLPSAINR KLSKGQSISA NLKWSYYLPT 
301:	FNLGMEDQFK INLGYNYRHI NQTSELNTLG ATKKKFAVSG VSAGIDGHIQ FTPKTIFNID 
361:	LTHHYYASKL PGSFGMERIG ETFNRSYHIS TASLGLSQEF AQGWHFSSQL SGQFTLQDIS 
421:	SIDLFSVTGT YGVRGFKYGG ASGERGLVWR NELSMPKYTR FQISPYAFYD AGQFRYNSEN 
481:	AKIYGEDMHT VSSAGLGIKT SPTQNLSLDA FVARRFANAN SDNLNGNKKR TSSPTTFWGR 
541:	LTFSF