TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.B.24.1.1









M. smegmatis porin, MspA (cation selective due to a high density of negative charges in the constriction zone, but it transports glucose, serine, hydrophilic β-lactams and (slowly) phosphate (Wolschendorf et al., 2007)) The MspC paralogue appears to have the same specificity as MspA. Both can also transport fluoroquinolones and chloramphenicol but not the larger erythromycin, kanamycin, and vancomycin (Danilchanka et al., 2008). Also allows uptake of ferric iron (Jones and Niederweis, 2010). The 3-d structure is known (PDB#1UUN). It is a β-barrel with N- and C-termini of their single hairpins on the outside, and their chains run in an anti-clockwise direction around the central pore. Both of these characteristics are opposite in most gram-negative bacterial β-barrels (Remmert et al., 2010).  Forms octameric voltage-gated nanopores (Rodrigues et al. 2011; Pavlenok et al. 2012) that can be used for nanopore sequencing (Pavlenok et al. 2012) that can be used for nanopore sequencing (Laszlo et al. 2016).

Bacteria
Actinobacteria
MspA of Mycobacterium smegmatis
*1.B.24.1.2









MspA porin (233aas; one N-terminal alpha-helical TMS).  This protein is almost identical to a cholate-transporting porin in R. jostii (RjpA; porin A) that is involved in cholate uptake (Somalinga and Mohn 2013).

Bacteria
Actinobacteria
MspA porin of Rhodococcus opacus (C1B943)
*1.B.24.1.3









MspA porin homologue (227aas; 1 N-terminal TMS) (shows significant similarity with members of both 1.B.24 and 1.B.58).

Bacteria
Actinobacteria
MspA porin of Gordonia effusa (H0QY58)
*1.B.24.1.4









MspA porin homologue (289aas; 1 N-terminal TMS)

Bacteria
Actinobacteria
MspA porin of Tsukamurella paurometabola (D5UQW2)
*1.B.24.1.5









RjpA outer membrane porin of 233 aas and 3 TMSs.  Transports bile acids such as cholate (Somalinga and Mohn 2013).

Bacteria
Actinobacteria
RjpA of Rhodococcus jostii
*1.B.24.1.6









RjpB outer membrane porin of 233 aas and 3 TMSs.  Transports bile acids such as cholate (Somalinga and Mohn 2013).

Bacteria
Actinobacteria
RjpB of Rhodococcus justii
*1.B.24.1.7









RjpC outer membrane porin of 283 aas and 1 - 3 TMSs.  Transports bile acids such as cholate (Somalinga and Mohn 2013).

Bacteria
Actinobacteria
RjpC of Rhodococcus justii
*1.B.24.1.8









RjpD outer membrane porin of 233 aas and 3 TMSs.  Transports bile acids such as cholate (Somalinga and Mohn 2013).

Bacteria
Actinobacteria
RjpD of Rhodococcus justii