TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.B.25.1.1









OprD2; OccD1; porin D transports cationic amino acids, peptides and other compounds: lysine, arginine, histidine, ornithine, basic di- and tri-peptides, and cationic antibiotics such as imipenem (n-formimidoylthienamycin) and other penems and carbapenems (Tamber et al., 2006).  The 3-d structure and drugs transported are known (4FOZ; Parkin and Khalid 2014).  OprD is the vitronectin receptor. Vitronectin enhances P. aeruginosa adhesion to host epithelial cells and thereby enhances virulence (Paulsson et al. 2015).  Loss promotes carbapenem resistance (Shen and Fang 2015; Cavalcanti et al. 2015).

Bacteria
Proteobacteria
OprD2 of Pseudomonas aeruginosa (P32722)
*1.B.25.1.2









OprE1 porin (anaerobically induced). May participate in chromate resistance (Rivera et al., 2008)
Bacteria
Proteobacteria
OprE1 of Pseudomonas aeruginosa (Q51510)
*1.B.25.1.3









OprE3 (OprQ) porin ().

Bacteria
Proteobacteria
OprE3 of Pseudomonas aeruginosa (O24779)
*1.B.25.1.4









PhaK phenylacetate/organic acid porin

Bacteria
Proteobacteria
PhaK of Pseudomonas putida (O84986)
*1.B.25.1.5









GusC (UidC) putative glucuronide porin (Liang et al., 2005).  Reported to enhance the activity of the UidB (GusB) glucuronide transporter (TC# 2.A.2.1.5). Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB protein.

Bacteria
Proteobacteria
GusC of E. coli (Q47706)
*1.B.25.1.6









Vanillate trafficing porin, VanP. 85% identical to OprD of Acinetobacter baumannii which when mutated confers MDR (Yang et al. 2015).

Bacteria
Proteobacteria
VanP of Acinetobacter sp. ADP1 (Q6FDI3)
*1.B.25.1.7









OpdO pyroglutamate-specific porin (Tamber et al., 2006)
Bacteria
Proteobacteria
OpdO of Pseudomonas aeruginosa (AAG05501)
*1.B.25.1.8









Anion-selective OpdK (OccK1 or OpdK) benzoate/vanillate-selective porin (Tamber et al., 2006Eren et al., 2012; Liu et al. 2012). The structure of the OpdK porin, specific for vanillate and related small aromatic acids, has been solved by x-ray crystallography (3SYS_A). It is a labile trimer with monomers of an 18 β-stranded barrel and with an inner diameter of 8Å (Biswas et al., 2008). Other substrates transported (but less well) include 4-nitrobenzoate, caproate, octanoate, carbenicillin, cefoxitin, tetracycline antibiotics, and carbapenem antibioitics (imipenem and meropenem) (Eren et al., 2012).  Molecular dynamic simulations and mutant analyses have been reported (Wang et al. 2012).

Bacteria
Proteobacteria
OpdK of Pseudomonas aeruginosa (AAG08283)
*1.B.25.1.9









OpdP glycine-glutamate-selective porin (Tamber et al., 2006)
Bacteria
Proteobacteria
OpdP of Pseudomonas aeruginosa (AAG07889)
*1.B.25.1.10









A tricarboxylate transporting porin, OdpH induced by and transports cis-aconitate, isocitrate and citrate; exhibits a large single channel conductance (Tamber et al., 2006; 2007)
Bacteria
Proteobacteria
OpdH of Pseudomonas aeruginosa (AAG04144)
*1.B.25.1.11









OpdB proline-selective porin (Tamber et al., 2006)
Bacteria
Proteobacteria
OpdB of Pseudomonas aeruginosa (AAG06088)
*1.B.25.1.12









OpdC or OccD2 histidine-selective porin (Tamber et al., 2006).  The 3-D structure and substrate spcificities are known (PDB 3SY9; Eren et al. 2012).

Bacteria
Proteobacteria
OpdC of Pseudomonas aeruginosa (AAG03552)
*1.B.25.1.13









Chitoporin, ChiP or YbfM of 468 aas. Takes up chitosugars such as chitobiose.  It also plays a role in carbapenem (imipenem) resistance.  The orthologue in Proteus mirabilis is ImpR, and that in Salmonella species is YbfM. It is subject to regulation by the small RNA, MicM (Tsai et al. 2015).  Loss of OmpC and OmpF results in poor growth, by expression of chiP restores growth (Knopp and Andersson 2015).

Bacteria
Proteobacteria
ChiP of E. coli (P75733)
*1.B.25.1.14









OdpF (OccK2) glucuronate-selective porin; may also transport benzoate and vanillate (Eren et al., 2012). 3-d structure is known (3SZD).

Bacteria
Proteobacteria
OdpF of Pseudomonas aeruginosa (Q9I6P8)
*1.B.25.1.15









Outer membrane porin
Bacteria
Bacteroidetes/Chlorobi group
Ftrac_3105 of Marivirga tractuosa
*1.B.25.1.16









Outer membrane porin
Bacteria
Proteobacteria
Tint_2055 of Thiomonas intermedia
*1.B.25.1.17









Outer membrane porin
Bacteria
Proteobacteria
Sdel_0469 of Sulfurospirillum deleyianum
*1.B.25.1.18









Outer membrane porin, OprD family
Bacteria
Aquificae
SULAZ_1441 of Sulfurihydrogenibium azorense
*1.B.25.1.19









Outer membrane porin, OprD family
Bacteria
Proteobacteria
PROVRUST_07396 of Providencia rustigianii DSM 4541
*1.B.25.1.20









Outer membrane porin
Bacteria
Proteobacteria
Sulku_2564 of Sulfuricurvum kujiense
*1.B.25.1.21









Outer membrane porin
Bacteria
Proteobacteria
Atc_1106 of Acidithiobacillus caldus
*1.B.25.1.22









Outer membrane porin
Bacteria
Proteobacteria
Sdel_0019 of Sulfurospirillum deleyianum
*1.B.25.1.23









Outer membrane porin, OprD family
Bacteria
Proteobacteria
Dsui_2952 of Azospira oryzae
*1.B.25.1.24









Outer membrane porin, OprD family
Bacteria
Proteobacteria
CBGD1_2399 of Campylobacterales bacterium GD 1
*1.B.25.1.25









Uncharacterized protein
Bacteria
Proteobacteria
SMGD1_0130 of Sulfurimonas gotlandica GD1
*1.B.25.1.26









Outer membrane porin
Bacteria
Proteobacteria
Sulku_1154 of Sulfuricurvum kujiense
*1.B.25.1.27









Outer membrane porin
Bacteria
Proteobacteria
Sputcn32_0255 of Shewanella putrefaciens
*1.B.25.1.28









Putative outer membrane porin
Bacteria
Proteobacteria
SMGD1_2744 of Sulfurimonas gotlandica GD1
*1.B.25.1.29









Outer membrane porin
Bacteria
Proteobacteria
Sdel_2087 of Sulfurospirillum deleyianum
*1.B.25.1.30









Outer membrane porin
Bacteria
Proteobacteria
Sulku_1034 of Sulfuricurvum kujiense
*1.B.25.1.31









Putative porin

Bacteria
Proteobacteria
Putative porin of Shewanella sediminis
*1.B.25.1.32









Outer membrane tyrosine-specific porin, OpdT (Tamber et al. 2006).

Bacteria
Proteobacteria
OpdT of Pseudomonas aeruginosa
*1.B.25.1.33









Putative porin

Bacteria
Aquificae
Porin of Sulfurihydrogenibium azorense
*1.B.25.1.34









The outer membrane porin, OdpQ of 421 aas.  opdQ is transcriptionally repressed under low oxygen but increased in the presence of nitrate. The nitrate-induced regulation is dependent on NarL via the NarXL two-component system. In addition, NaCl-induced osmotic stress increases OpdQ production among most of the clinical strains evaluated (Fowler and Hanson 2015).

Bacteria
Proteobacteria
OdpQ of Pseudomonas aeruginosa
*1.B.25.2.1









BenP porin (Clark et al. 2002).  Probably transports aromatic compounds such as benzoate for degradation.

Bacteria
Proteobacteria
BenP of Acinetobacter sp.ADP1 (Acinetobacter baylyi)
*1.B.25.3.1









Putative porin of 278 aas

Bacteria
Chlamydiae/Verrucomicrobia group
PP of Lentisphaera araneosa