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1.B.27 The Helicobacter Outer Membrane Porin (Hop) Family

The Hop family consists of 31 outer membrane proteins in Helicobacter pylori. Five such proteins, HopA-HopE have been shown to function as porins both in bacterial outer membranes and in reconstituted planar bilayer membranes. The HopE protein appears to form a β-barrel with 16 transmembrane amphipathic β-strands. It is the smallest of the characterized Hop family members, but it forms the largest channels with a single channel conductance of 1.5 nS in 1M KCl (Bina et al. 2000).

The generalized transport reaction catalyzed by Hop family porins is:

solute (out) solute (periplasm)

References associated with 1.B.27 family:

Bina, J., M. Bains, and R.E. Hancock. (2000). Functional expression in Escherichia coli and membrane topology of porin HopE, a member of a large family of conserved proteins in Helicobacter pylori. J. Bacteriol. 182: 2370-2375. 10762234
de Jonge, R., R.G. Pot, R.J. Loffeld, A.H. van Vliet, E.J. Kuipers, and J.G. Kusters. (2004). The functional status of the Helicobacter pylori sabB adhesin gene as a putative marker for disease outcome. Helicobacter 9: 158-164. 15068418
Kennemann, L., B. Brenneke, S. Andres, L. Engstrand, T.F. Meyer, T. Aebischer, C. Josenhans, and S. Suerbaum. (2012). In vivo sequence variation in HopZ, a phase-variable outer membrane protein of Helicobacter pylori. Infect. Immun. 80: 4364-4373. 23027539
Lienlaf, M., J.P. Morales, M.I. Díaz, R. Díaz, E. Bruce, F. Siegel, G. León, P.R. Harris, and A. Venegas. (2010). Helicobacter pylori HopE and HopV porins present scarce expression among clinical isolates. World J Gastroenterol 16: 320-329. 20082477
Peck, B., M. Ortkamp, K.D. Diehl, E. Hundt, and B. Knapp. (1999). Conservation, localization and expression of HopZ, a protein involved in adhesion of Helicobacter pylori. Nucleic Acids Res 27: 3325-3333. 10454640
Tomb, J.F., O. White, A.R. Kerlavage, R.A. Clayton, G.G. Sutton, R.D. Fleischmann, K.A. Ketchum, H.P. Klenk, S. Gill, B.A. Dougherty, K. Nelson, J. Quackenbush, L. Zhou, E.F. Kirkness, S. Peterson, B. Loftus, D. Richardson, R. Dodson, H.G. Khalak, A. Glodek, K. McKenney, L.M. Fitzegerald, N. Lee, M.D. Adams, E.K. Hickey, D.E. Berg, J.D. Gocayne, T.R. Utterback, J.D. Peterson, J.M. Kelley, M.D. Cotton, J.M. Weidman, C. Fujii, C. Bowman, L. Watthey, E. Wallin, W.S. Hayes, M. Borodovsky, P.D. Karp, H.O. Smith, C.M. Fraser, and J.C. Venter. (1997). The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388: 539-547. 9252185