TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.B.38.1.1









Large non-selective MSP porin with short lived large ion conduction (Mathers et al. 1996). Contains repeated MOSP_N and MOSP_C domains.

Bacteria
Spirochaetes
Msp of Treponema denticola
*1.B.38.1.2









Treponema repeat protein K (TprK), an outer membrane surface exposed variable antigen which plays a role in immune evasion and persistence (Giacani et al. 2012; Reid et al. 2014).

Bacteria
Spirochaetes
TprK of Treponema pallidum
*1.B.38.1.3









Repeat protein, TprEb

Bacteria
Spirochaetes
Repeat protein, TprEb
*1.B.38.1.4









Major outer membrane sheath protein, Msp, of 543 aas.  Msp has a bipartide structure and exists as periplasmic and outer membrane-integrated trimeric conformers (Anand et al. 2013).  The N-terminal domain (residues 77 - 286) does not insert into the membrane, but the C-terminal domain (residues 332 - 543) does to form pores (Anand et al. 2013).  It resembles the surface exposed variable antigen, TprK (Giacani et al. 2012) which plays roles in immune evasion and persistence.

Bacteria
Spirochaetes
Major outer sheath protein, Msp, of Treponema denticola
*1.B.38.1.5









Outer membrane bipartite trimeric porin of 598 aas with an N-terminal MOSPN domain (in the periplasm), and a C-terminal MOSPC domain (cell surface localized), TprC/TprD.  The MOSPN domain confers envelope integrity by anchoring the C-terminal porin domain to periplasmic structural constituents (Anand et al. 2015).

Bacteria
Spirochaetes
TprC of Treponema pallidum
*1.B.38.1.6









Outer membrane trimeric porin, TprI of 598 aas with a structure similar to that of TprC (TC# 1.B.38.1.5) (Anand et al. 2015).

Bacteria
Spirochaetes
TprI of Treponema pallidum
*1.B.38.2.1









Putative outer membrane protein of 460 aas. Shows some sequence similarity to autotransporters (1.B.40)

Bacteria
Spirochaetes
OMP of Spirochaeta thermophila
*1.B.38.2.2









Putative outer membrane protein of 446 aas.  Shows some sequence similiarity to autotransporters (1.B.40)

Bacteria
Spirochaetes
OMP of Spirochaeta thermophila
*1.B.38.3.1









Putative sheath protein of 520 aas with 14 putative β-TMSs at the N-terminus and a fairly long C-terminal extension.

Bacteria
Spirochaetes
Putative sheath protein of Treponema brennaborense
*1.B.38.3.2









Putative outer membrane protein of 575 aas and 24 putative β-TMSs, MspA

Bacteria
Spirochaetes
MspA of Treponema maltophilum
*1.B.38.3.3









Putative outer membrane protein of 590 aas and 22 putative β-TMSs.

Bacteria
Spirochaetes
OMP of Treponema lecithinolyticum