1.B.38.1.4
Major outer membrane sheath protein, Msp, of 543 aas. Msp has a bipartide structure and exists as periplasmic and outer membrane-integrated trimeric conformers (Anand et al. 2013). The N-terminal domain (residues 77 - 286) does not insert into the membrane, but the C-terminal domain (residues 332 - 543) does to form pores (Anand et al. 2013). It resembles the surface exposed variable antigen, TprK (Giacani et al. 2012) which plays roles in immune evasion and persistence.
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| Accession Number: | F7IWF6 |
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| Protein Name: | Major outer sheath protein |
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| Length: | 543 |
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| Molecular Weight: | 58270.00 |
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| Species: | Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [243275] |
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| Number of TMSs: | 1 |
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| Substrate |
small molecules |
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1: MKKILAILMI LVLVGGVAFA QLTPQVTAKA SVNWGIDFGA GKNAKAQHGF ENLLDAKVVI
61: PLYMGTLNSK TEGDVRMNFD LGVNLAYRFY DQLSNSASPH VAWDSDAEFK LWRKTLSDMS
121: ASIHFFGGYM NVYGRPDFST NYAQIWSPIR DNGVAWGPET SGDITGFGTK LGYASDDLAG
181: TGLKFDAGLK FGSNGSWKAK GTTAQDKFKV VDLKVGDTLI AGATYYKQNG IDAEGKPIFS
241: STAAVFAAPP TVGAGEDGKY LVKTASTATG PAANKYAFGL DLSLGYDKWV TLDFGINATF
301: DNVKDFGKAG VHEDVAAGSN PDKPYLGMGL KLGSKPVDGL ALTLAMDALM NVGTDSKVAF
361: DLRFDASYKW VALGAYFGND LSAYAGKDKN NKAIGDMAAM IAFKSAASGD TNFVEGLAFG
421: VDFRLNHLLS AVPTGDKSTL PMGISAWVNY KYALTDSMWV KPYANFWGET NRKSIDASKT
481: DKFFGVAYKV GATFSPAEKI EIDTYWSQGK LSWNKYEGTE GMISAPAFDA HNGTFVIGVK
541: VIY
