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1.B.38.1.5
Outer membrane bipartite trimeric porin of 598 aas with an N-terminal MOSPN domain (in the periplasm), and a C-terminal MOSPC domain (cell surface localized), TprC/TprD.  The MOSPN domain confers envelope integrity by anchoring the C-terminal porin domain to periplasmic structural constituents (Anand et al. 2015). Selection pressures exerted within human populations drive T. pallidum subsp. pallidum TrpC diversity by mutation of loop regions and by recombination(Kumar et al. 2018).

Accession Number:O88138
Protein Name:Tpr protein C
Length:598
Molecular Weight:64736.00
Species:Treponema pallidum (strain Nichols) [243276]
Number of TMSs:1
Substrate small molecules

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGRQVMQAGV LAGMVCAASG YAGVLTPQVS GTAQLQWGIA FQKNPRTGPG KHTHGFRTTN 
61:	SLTISLPLVS KHTHTRRGEA RSGVWAQLQL KDLAVELASS KSSTALSFTK PTASFQATLH 
121:	CYGAYLTVGT SPSCVVNFAQ LWKPFVTRAY SEKDTRYAPG FSGSGAKLGY QAHNVGNSGV 
181:	DVDIGFLSFL SNGAWDSTDT THSKYGFGAD ATLSYGVDRQ RLLTLELAGN ATLDQNYVKG 
241:	TEDSKNENKT ALLWGVGGRL TLEPGAGFRF SFALDAGNQH QSNAHAQTQE RAILKAREVF 
301:	RRVEGKLVQN LPNIMMPPGI TEQTTLIEMV GLAALIAEGT LGSAIQTVLA AGALAALVSQ 
361:	LVPNIEQGVR DVFRSSDPRV VTAKLLAFLE RAPMNALNID ALLRMQWKWL SSGIYFATAG 
421:	TNIFGKRVFA TTRAHYFDFA GFLKLETKSG DPYTHLLTGL NAGVEARVYI PLTYIRYRNN 
481:	GGYELNGAVP PGTINMPILG KAWCSYRIPL GSHAWLAPHT SVLGTTNRFN IINPAGNLLN 
541:	ERALQYQVGL TFSPFEKVEL SAQWEQGVLA DAPYMGIAES IWSERHFGTL VCGMKVTW