TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.B.6.1.1









Weakly anion-selective OmpA porin.  Can exist in two distinct conductance states (Arora et al. 2000).  May function in the transport of phenylpropanoids (resveratrol, naringenin and rutin) (Zhou et al. 2014).

Bacteria
Proteobacteria
OmpA of E. coli (P0A910)
*1.B.6.1.2









OmpF (OprF) porin.  The N-terminal domain has pore activity (Saint et al. 2000).  The protein can exist in multiple conformations of variable conductivity (Nestorovich et al. 2006).  Factors affecting the folding of Pseudomonas aeruginosa OprF porin into the one-domain open conformer have been studied by Sugawara et al. (2010). OprF is a complement component C3 receptor (Mishra et al. 2015).

Bacteria
Proteobacteria
OmpF (OprF) of Pseudomonas aeruginosa (P13794)
*1.B.6.1.3









OmpATb (ArfA). The central domain (residues 73-220) has been reported to exhibit channel activity (Molle et al., 2006). However through structural analyses, Teriete et al. (2010) have provided evidence that it does not form a β-barrel, causing them to propose that it does not have porin activity. Its expression is dependent on small single TMS membrane proteins which are encoded in a single operon with it (Veyron-Churlet et al., 2011). The rv0899 gene is part of an operon (rv0899-rv0901) that is required for fast ammonia secretion, pH neutralization, and growth of M. tuberculosis in acidic environments, and OmpATb may allow secretion (Song et al. 2011). Homologues are widespread in bacteria with functions in nitrogen metabolism, adaptation to nutrient poor environments, and/or establishing symbiosis with host organisms (Marassi, 2011).

Bacteria
Actinobacteria
OmpATb of Mycobacterium tuberculosis (P65593)
*1.B.6.1.4









HMP-AB outer membrane porin, OmpAb or Omp38 (Gribun et al., 2004).  Shown to be the principle porin with an inner diameter of 2nm.  Allows transport of cephalothin, cephaloridine, other antibiotics and small molecules across the outer membrane (Sugawara and Nikaido 2012). Structural studies have been reported (Vashist and Rajeswari 2006).

Bacteria
Proteobacteria
HMP-AB of Acinetobacter baumannii (Q8KWW6)
*1.B.6.1.5









The OmpA-OmpF porin (OOP) family member, GmpA (involved in acetic acid fermentation; under quorum sensing control) (Iida et al., 2008). (most similar to 1.B.6.1.4)

Bacteria
Proteobacteria
GmpA of Gluconacetobacter intermedius (B3A000)
*1.B.6.1.6









Outer membrane protein 40 (Omp40) (PG33)
Bacteria
Bacteroidetes/Chlorobi group
PG_0694 of Porphyromonas gingivalis
*1.B.6.1.7









OmpA homologue

Bacteria
Firmicutes
OmpA homologue of Megasphaera elsdenii
*1.B.6.1.8









OmpA homologue

Bacteria
Firmicutes
OmpA homologue of Megasphaera sp. UPII 135-E
*1.B.6.1.9









OMP_b-br1 family protein

Bacteria
Firmicutes
Outer membrane protein of Megasphaera elsdenii
*1.B.6.1.10









Outer membrane insertion signal domain protein

Bacteria
Firmicutes
OMISD protein of Veillonella atypica
*1.B.6.1.11









OmpA of 210 aas. The 3-d structure has been solved by NMR (Renault et al. 2010), and its dynamics have been examined (Renault et al. 2009).

Bacteria
Proteobacteria
OmpA of Klebsiella pneumoniae
*1.B.6.1.12









Omp34 outer membrane porin of 346 aas.  Also known as the Major antigen Fc binding protein (White et al. 1998).

Bacteria
Proteobacteria
Omp34 of Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
*1.B.6.1.13









Putative porin of 253 aas

Bacteria
Actinobacteria
Putative porin of Nocardioidaceae bacterium Broad-1
*1.B.6.1.14









Outer membrane protein of 638 aas, OmpF

Bacteria
Bacteroidetes/Chlorobi group
OmpF of Cecembia lonarensis
*1.B.6.1.15









OmpA/F

Bacteria
Spirochaetes
OmpA/F of Treponema pallidum
*1.B.6.1.16









OmpA family porin of 410 aas

Bacteria
Proteobacteria
OmpA porin of Phenylobacterium zucineum
*1.B.6.1.17









Putative OmpF homologue

Bacteria
Spirochaetes
Putative OmpF homologue of Leptospira interrogans
*1.B.6.1.18









Outer membrane protein of 210 aas and 8 putative TMSs

Bacteria
Proteobacteria
OMP of Thiothrix nivea
*1.B.6.1.19









Outer membrane protein of 218 aas and 8 putative TMSs

Bacteria
Bacteroidetes/Chlorobi group
OMP of Mariniradius saccharolyticus
*1.B.6.1.20









OmpA homologue of 189 aas

Bacteria
Spirochaetes
OmpA homologue of Leptospira biflexa
*1.B.6.1.21









OmpA-type porin of 160 aas, YfiB The yfiRNB locus in E. coli CFT073 contains genes for YfiN, a diguanylate cyclase, and its activity regulators, YfiR and YfiB.(Raterman et al. 2013).

Bacteria
Proteobacteria
YfiB of E. coli
*1.B.6.1.22









Constitutively expressed OmpA of 365 aas (Gao et al. 2015).

Bacteria
Proteobacteria
OmpA of Shewanella oneidensis
*1.B.6.1.23









OmpA of 354 aas with 1 N-terminal α-TMS, 10 putative β-TM Strands and a periplasmic C-terminal domain, probably a peptidoglycan-binding domain (Khalid et al. 2008).  Plays a role in virulence (pneumonia in pigs and ruminants) (Verma et al. 2016; Confer and Ayalew 2013) and has been used for vaccine development (Dabo et al. 2008).

Bacteria
Proteobacteria
OmpA of Pasteurella multocida
*1.B.6.2.1









Outer membrane porin precursor, OmpX (8 TM β-strands) (NMR structures in lipid bilayers solved (Mahalakshmi et al., 2007; Mahalakshmi and Marassi, 2008)).

Bacteria
Proteobacteria
OmpX of E. coli (P0A917)
*1.B.6.2.2









The attachment inversion locus (Ail) (Bartra et al., 2007).  Membrane-bound proteins, Ail and OmpF, are involved in the adsorption of T7-related bacteriophage (Zhao et al. 2013).

Bacteria
Proteobacteria
Ail of Yersinia pestis (Q0WCZ9)
*1.B.6.2.3









Opacity family porin protein
Bacteria
Proteobacteria
UMN179_00549 of Gallibacterium anatis
*1.B.6.2.4









Opacity family porin protein
Bacteria
Proteobacteria
UMN179_00948 of Gallibacterium anatis
*1.B.6.2.5









Neisserial surface protein A, NspA of 174 aas and 8 TMSs (Hou et al. 2003).

Bacteria
Proteobacteria
NspA of Neisseria meningitidis
*1.B.6.2.6









Porin opacity type
Bacteria
Proteobacteria
AM202_02155 of Actinobacillus minor 202
*1.B.6.2.7









Arginine transporter permease subunit ArtM
Bacteria
Proteobacteria
GGC_0882 of Haemophilus haemolyticus M21621
*1.B.6.2.8









Opa-like protein A
Bacteria
Proteobacteria
E9U_09445 of Moraxella catarrhalis BC8
*1.B.6.2.9









Surface protein A
Bacteria
Proteobacteria
NspA of Neisseria wadsworthii 9715
*1.B.6.2.10









Outer membrane porin, OmpX of 171 aas (Dupont et al. 2004).

Bacteria
Proteobacteria
OmpX of Enterobacter (Aerobacter) aerogenes
*1.B.6.2.11









Outer membrane porin, opacity type, of 189 aas

Bacteria
Bacteroidetes/Chlorobi group
OMP of Prosthecochloris vibrioformis
*1.B.6.2.12









Outer membrane porin, opacity type, of 230 aas

Bacteria
Bacteroidetes/Chlorobi group
OMP of Chlorobaculum parvum
*1.B.6.2.13









Putative invasin of 242 aas

Bacteria
Proteobacteria
Putative invasin of E. coli
*1.B.6.2.14









Uncharacterized protein of 290 aas

Bacteria
Proteobacteria
UP of Nitrobacter hamburgensis
*1.B.6.2.15









Putative porin of 199 aas

Bacteria
Proteobacteria
Putative porin of Rhodanobacter thiooxydans
*1.B.6.2.16









Uncharacterized protein of 196 aas

Bacteria
Proteobacteria
UP of Vibrio fischeri
*1.B.6.2.17









Putative porin of 195 aas

Bacteria
Proteobacteria
Putative porin of Vibrio alginolyticus
*1.B.6.2.18









Uncharacterized protein of 186 aas

Bacteria
Proteobacteria
UP of Agarivorans albus
*1.B.6.2.19









Putative porin of 182 aas

Bacteria
Proteobacteria
PP of Grimontia hollisae
*1.B.6.2.20









Ail/Lom protein of 199 aas

Bacteria
Proteobacteria
Ail/Lom protein of E. coli
*1.B.6.3.1









Putative porin of 197 aas

Bacteria
Chlamydiae/Verrucomicrobia group
PP of Opitutaceae bacterium TAV1
*1.B.6.3.2









Putative porin of 277 aas

Bacteria
Chlamydiae/Verrucomicrobia group
PP of Coraliomargarita sp. CAG:312
*1.B.6.3.3









Putative porin

Bacteria
Chlamydiae/Verrucomicrobia group
PP of Opitutus terrae
*1.B.6.4.1









Putative porin of 183 aas

Bacteria
Proteobacteria
Putative porin of Vibrio parahaemolyticus
*1.B.6.5.1









Outer membrane protein of 205 aas and 8 putative TMSs.

Bacteria
Fibrobacteres/Acidobacteria group
OMP of Fibrobacter succinogens
*1.B.6.5.2









Outer membrane protein of 197 aas and 8 putative TMSs.

Bacteria
Fibrobacteres/Acidobacteria group
OMP of Fibrobacter succinogenes
*1.B.6.5.3









Outer membrane protein of 534 aas and 6 - 22 beta strands.

Bacteria
Spirochaetes
OMP of Turneriella parva
*1.B.6.5.4









Outer membrane protein of 211 aas and 8 beta strands.

Bacteria
Proteobacteria
OMP of Myxococcus xanthus
*1.B.6.5.5









Outer membrane protein of 201 aas and 9 putative beta strands.

Bacteria
Proteobacteria
OMP of Vibrio tubiashii
*1.B.6.5.6









Outer membrane protein, OmpA of 196 aas and 8 putative TMSs

Bacteria
Proteobacteria
OmpA of Aliivibrio salmonicida
*1.B.6.6.1









Outer membrane protein of 201 aas and 8 putative β-TMSs.

Bacteria
Bacteroidetes/Chlorobi group
OMP of Cyclobacterium marinum
*1.B.6.6.2









Outer membrane protein of 224 aas and 8 TMSs

Bacteria
Bacteroidetes/Chlorobi group
OMP of Dyadobacter fermentans
*1.B.6.6.3









Outer membrane protein of 204 aas and 8 TMSs

Bacteria
Bacteroidetes/Chlorobi group
OMP of Solitalea canadensis
*1.B.6.6.4









Outer membrane protein of 221 aas and 8 TMSs

Bacteria
Bacteroidetes/Chlorobi group
OMP of Psychroflexus torquis
*1.B.6.6.5









Outer membrane protein of 222 aas

Bacteria
Bacteroidetes/Chlorobi group
OMP of Echinicola vietnamensis
*1.B.6.6.6









Outer membrane protein of 199 aas

Bacteria
Bacteroidetes/Chlorobi group
OMP of Chitinophaga pinensis
*1.B.6.6.7









Porin of 193 aas and 8 beta strands

Bacteria
Bacteroidetes/Chlorobi group
Porin of Flavobacterium johnsoniae
*1.B.6.6.8









Porin of 180 aas and 8 beta strands

Bacteria
Nitrospirae
Porin of Candidatus Nitrospira defluvii
*1.B.6.6.9









Porin of 207 aas and 8 beta strands

Bacteria
Proteobacteria
Porin of Myxococcus xanthus
*1.B.6.6.10









Putative porin of 157 aas and 8 beta strands

Bacteria
Bacteroidetes/Chlorobi group
Putative porin of Paludibacter propionicigenes
*1.B.6.6.11









Uncharacterized protein of 208 aas.

Bacteria
Bacteroidetes/Chlorobi group
UP of Pedobacter saltans
*1.B.6.6.12









Putative porin of 192 aas

Bacteria
Bacteroidetes/Chlorobi group
Putative porin of Capnocytophaga sputigena
*1.B.6.7.1









Outer membrane protein of 257 aas and 8 beta strands

Bacteria
Bacteroidetes/Chlorobi group
OMP of Bacteroides fragilis
*1.B.6.8.1









Porin of 224 aas and 8 beta strands, TtoA (Estrada Mallarino et al. 2015).  The crystal structure is known (3DZM) (Nesper et al. 2008). The 2.8 Å structure reveals a transmembrane 8 stranded β-barrel, an extracellular cation-binding region and an external 5-β stranded sheet (Brosig et al. 2009).

Bacteria
Deinococcus-Thermus
Porin of Thermus thermophilus
*1.B.6.8.2









Putative porin of 222 aas.

Bacteria
Deinococcus-Thermus
Putative porin of Deinococcus geothermalis
*1.B.6.9.1









Uncharacterized protein of 186 aas.

Bacteria
Bacteroidetes/Chlorobi group
UP of Ignavibacterium album
*1.B.6.9.2









Uncharacterized putative porin protein of 189 aas.

Bacteria
Bacteroidetes/Chlorobi group
UP of Owenweeksia hongkongensis
*1.B.6.9.3









Uncharacterized putative porin of 205 aas

Bacteria
Bacteroidetes/Chlorobi group
Putative porin of Owenweeksia hongkongensis
*1.B.6.9.4









Uncharacterized protein of 167 aas

Bacteria
Bacteroidetes/Chlorobi group
UP of Elizabethkingia anophelis