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1.B.69 The Peroxysomal Membrane Porin 4 (PxMP4) Family

The PxMP4 Family consists of proteins in peroxysomes of poorly defined function called PxMP4 or PMP24.  However, they are homologous to mitochondrial inner membrane consituents of the Tim complex, Tim 17, Tim22 and Tim23 as well as chloroplast OEP16 proteins and a small subunit of the NADH:ubiquinone oxidoreductase complex; see small subunit in the fungal enzyme complex of 200 aas (P25710). The human PMP24 is silenced by DNA methylation in prostate cancer (Zhang et al. 2010). PxMP4 probably is a porin with an important transport function in peroxysomes (Visser et al. 2007).

References associated with 1.B.69 family:

Beck, R., F. Adolf, C. Weimer, B. Bruegger, and F.T. Wieland. (2009). ArfGAP1 activity and COPI vesicle biogenesis. Traffic 10: 307-315. 19055691
Visser, W.F., C.W. van Roermund, L. Ijlst, H.R. Waterham, and R.J. Wanders. (2007). Metabolite transport across the peroxisomal membrane. Biochem. J. 401: 365-375. 17173541
Zhang, X., M. Wu, H. Xiao, M.T. Lee, L. Levin, Y.K. Leung, and S.M. Ho. (2010). Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. Prostate 70: 765-776. 20054818