TCDB is operated by the Saier Lab Bioinformatics Group

1.B.76 The Copper Resistance Putative Porin (CopB) Family

The CopB family consists of proteins with about 420 aas with a single N-terminal hydrophobic TMS, followed by a hydrophilic region of about 200 residues, followed by a beta structured domain predicted to be an outer membrane beta barrel domain by PRED-TMBB.  These proteins show similarity to the C-terminal domain of iron oxidase in TC family 2.A.108.1 (Behlau et al. 2011).

References associated with 1.B.76 family:

Behlau, F., B.I. Canteros, G.V. Minsavage, J.B. Jones, and J.H. Graham. (2011). Molecular characterization of copper resistance genes from Xanthomonas citri subsp. citri and Xanthomonas alfalfae subsp. citrumelonis. Appl. Environ. Microbiol. 77: 4089-4096. 21515725
Cortes, L., A.G. Wedd, and Z. Xiao. (2015). The functional roles of the three copper sites associated with the methionine-rich insert in the multicopper oxidase CueO from E. coli. Metallomics 7: 776-785. 25679350
Kataoka, K., H. Kogi, S. Tsujimura, and T. Sakurai. (2013). Modifications of laccase activities of copper efflux oxidase, CueO by synergistic mutations in the first and second coordination spheres of the type I copper center. Biochem. Biophys. Res. Commun. 431: 393-397. 23337502
Su, J., L. Deng, L. Huang, S. Guo, F. Liu, and J. He. (2014). Catalytic oxidation of manganese(II) by multicopper oxidase CueO and characterization of the biogenic Mn oxide. Water Res 56: 304-313. 24699422
Wijekoon, C.J., T.R. Young, A.G. Wedd, and Z. Xiao. (2015). CopC protein from Pseudomonas fluorescens SBW25 features a conserved novel high-affinity Cu(II) binding site. Inorg Chem 54: 2950-2959. 25710712