TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.B.8.1.3
VDAC1 porin. > 99% identical to human (P21796) and mouse (60932) VDAC1. Mammals possess three VDACs (VDAC1, 2 and 3) encoded by three genes, but they are all similar in sequence (~60-70% identical) (Messina et al., 2011).  The 3-d structure of the human VDAC1 is known (PDB ID 2JK4; Bayrhuber et al. 2008).  Reviewed by Shoshan-Barmatz et al. 2015.  VDAC1 is found both in mitochondria and the plasma membrane (Lawen et al. 2005) where it may cause cytoplasmic ATP loss.. It may be involved in cancer (Shoshan-Barmatz et al. 2017) and Alzheimer's disease (AD) (Shoshan-Barmatz et al. 2018). Along with its low toxicity profile and high antioxidant activity, the gallic acid derivative, AntiOxBEN3, strongly inhibits calcium-dependent mitochondrial permeability transition pore (mPTP) opening (Teixeira et al. 2018). VDAC dimerization plays a role in mitochondrial metabolic regulation and apoptosis in response to cytosolic acidification during cellular stress, and E73 is involved (Bergdoll et al. 2018). Inhibiting VDAC1 overproduction and plasma membrane insertion in β-cells preserves insulin secretion in diabetes (Zhang et al. 2018).

Accession Number:P45879
Protein Name:POR1 aka VDAC1
Length:283
Molecular Weight:30741.00
Species:Bos taurus (Bovine) [9913]
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1
Substrate small molecules

Cross database links:

eggNOG: maNOG11150
RefSeq: NP_776910.2   
Entrez Gene ID: 282119   
Pfam: PF01459   
KEGG: bta:282119   

Gene Ontology

GO:0005741 C:mitochondrial outer membrane
GO:0005886 C:plasma membrane
GO:0046930 C:pore complex
GO:0000166 F:nucleotide binding
GO:0008308 F:voltage-gated anion channel activity
GO:0006820 P:anion transport
GO:0006915 P:apoptosis
GO:0055085 P:transmembrane transport

References (2)

[1] “Cloning and in situ localization of a brain-derived porin that constitutes a large-conductance anion channel in astrocytic plasma membranes.”  Dermietzel R.et.al.   7507248
[2] “Location of the dicyclohexylcarbodiimide-reactive glutamate residue in the bovine heart mitochondrial porin.”  De Pinto V.et.al.   7685355
Structure:
2jk4   2k4t   3emn   5jdp     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE TTKVTGSLET 
61:	KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD SSFSPNTGKK NAKIKTGYKR 
121:	EHINLGCDVD FDIAGPSIRG ALVLGYEGWL AGYQMNFETA KSRVTQSNFA VGYKTDEFQL 
181:	HTNVNDGTEF GGSIYQKVNK KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS 
241:	SLIGLGYTQT LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA