TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.B.8.1.1









Voltage-dependent anion channel (VDAC) porin

Eukaryota
Fungi
Mitochondrial outer membrane VDAC of Saccharomyces cerevisiae
*1.B.8.1.2









VDAC3 porin.  The human orthologue forms small pores in membranes (Checchetto et al. 2014).  VDAC3 is a sensor of the oxidative state in the mitochondrial intermembrane space, and cysteyl residue modification appears to play a role (Reina et al. 2016).

Eukaryota
Metazoa
Mitochondrial outer membrane VDAC3 of Mus musculus
*1.B.8.1.3









VDAC porin. Identical to human VDAC (P21798). Mammals possess three VDACs encoded by three genes, but they are all similar in sequence (~60-70% identical) (Messina et al., 2011).  The 3-d structure of the human VDAC is known (PDB ID 2JK4; Bayrhuber et al. 2008).  Reviewed by Shoshan-Barmatz et al. 2015

Eukaryota
Metazoa
Plasma membrane VDAC of Bos taurus
*1.B.8.1.4









VDAC porin.  The open state has a weak anion selectivity whereas the closed state is cation-selective.

Eukaryota
Viridiplantae
Mitochondrial outer membrane VDAC of Triticum aestivum
*1.B.8.1.5









Non green plastid porin
Eukaryota
Viridiplantae
Plastid porin of Pisum sativum
*1.B.8.1.6









Voltage-dependent anion-selective porin1 (Porin-1, VDAC or Por-1) (De Pinto et al. 1989; Aiello et al., 2004) (one of three paralogues). Mutations in VDAC leads to neurologic dysfunction and male infertility in Drosophila  (Graham et al., 2010).  Porin 1 is abundantly expressed in both male and female germ cell tissues; Porin 2 is abundant in testis but in small amounts in ovaries. The immuno-histological stain of ovaries shows that Porin isoform 1 is selectively targeted to follicular cells while Porin isoform 2 is present in mitochondria of the epithelial sheath cells of the ovariole (Guarino et al. 2006; Specchia et al. 2008).

Eukaryota
Metazoa
Porin 1 of Drosophila melanogaster
(Q94920)
*1.B.8.1.7









Voltage-independent, cation-selective porin2 (Porin-2 or Por-2) (converted to anion selective by changing Glu-66 and Glu-163 to lysines; Aiello et al., 2004). One of three paralogues (Craigen and Graham, 2008).  Porin 1 is abundantly expressed in both male and female germ cell tissues; Porin 2 is abundant in testis but in small amounts in ovaries. The immuno-histological stain of ovaries shows that Porin 1 is selectively targeted to follicular cells while Porin 2 is present in mitochondria of the epithelial sheath cells of the ovariole (Specchia et al. 2008).

Eukaryota
Metazoa
Porin 2 of Drosophila melanogaster
(Q9VKP2)
*1.B.8.1.8









 

Rice VDAC4.  Channels formed in planar bilayers exhibit large conductance (4.6 ± 0.3 nS in 1 M KCl), strong voltage dependence and weak anion selectivity. The open state of the channel is  permeable to ATP (Godbole et al. 2011).

Eukaryota
Viridiplantae
VDAC4 of Oryza sativa
*1.B.8.1.9









Mitochondrial outer membrane porin, VDAC, of 292 aas (De Pinto et al. 1989).

Eukaryota
Metazoa
VDAC of Drosophila melanogaster
*1.B.8.1.10









Outer membrane porin, VDAC of 346 aas.

Eukaryota
Bangiophyceae
VDAC of Galdieria sulphuraria
*1.B.8.1.11









Porin, VDAC of 309 aas

Eukaryota
Bangiophyceae
VDAC of Galdieria sulphuraria
*1.B.8.1.12









Mitochondrial outer membrane voltage-dependent anion-selective channel protein 2, VDAC-2 of 294 aas.  Protein:micelle rations and cysteine residues in the protein influence VDAC2 stability and unfolding rates (Maurya and Mahalakshmi 2014; Maurya and Mahalakshmi 2014).  VDAC-2  performs a different subset of regulatory functions than VDAC1. It has anti-apoptotic features and contributes to gametogenesis.It may also regulate ROS, steroidogenesis and mitochondria-associated endoplasmic reticulum membrane regulatory pathways (Maurya and Mahalakshmi 2015).  Plays a role in mitochondrial import of Bak and tBid-induced apoptosis (Naghdi et al. 2015).

Eukaryota
Metazoa
VDAC2 of Homo sapiens
*1.B.8.1.13









Mitochondrial outer membrane porin, PorA or VDAC (Troll et al. 1992).

Eukaryota
Dictyosteliida
Mitochondrial outer membrane porin of Dictyostelium discoideum (Q01501)
*1.B.8.1.14









Voltage-dependent anion-selective channel (VDAC) protein of 282 aas

Eukaryota
Albuginales
VDAC of Albugo laibachii
*1.B.8.1.15









VDAC1 of 276 aas, one of five isoforms.  A knock out mutation (Δvdac1) resulted in abnormal ovule formation during female gametogenesis, and both the mitochondrial transmembrane potential and ATP synthesis were reduced (Pan et al. 2014).

Eukaryota
Viridiplantae
VDAC1 of Arabidopsis thaliana
*1.B.8.1.16









Voltage-dependent anion channel, VDAC, of 283 aas

Eukaryota
Metazoa
VDAC of Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus)
*1.B.8.2.1









19 β-stranded barrel translocase across the outer membrane, Tom40 (Pfam Porin 3 Superfamily).

Eukaryota
Fungi
Tom40 of Saccharomyces cerevisiae
*1.B.8.2.2









Tom40 of 344 aas

Eukaryota
Metazoa
Tom40 of Drosophila melanogaster
*1.B.8.2.3









Eukaryotic porin family, Tom40-2 of 310 aas

Eukaryota
Viridiplantae
Tom40 of Arabidopsis thaliana
*1.B.8.2.4









Tom40 of 361 aas

Eukaryota
Longamoebia
Tom40 of Acanthamoeba castellanii
*1.B.8.2.5









Mitochondrial import receptor, Tom40 of 361 aas

Eukaryota
Metazoa
Tom40 of Homo sapiens
*1.B.8.2.6









Tom40 of 314 aas

Eukaryota
Dictyosteliida
Tom40 of Dictyostelium discoideum
*1.B.8.2.7









Tom40 of 264 aas

Eukaryota
Bacillariophyta
Tom40 of Thalassiosira occanica
*1.B.8.2.8









Tom40 of 301 aas

Eukaryota
Metazoa
Tom40 of Caenorhabditis elegans
*1.B.8.2.9









Mitochondrial import receptor, Tom40 of 394 aas

Eukaryota
Apicomplexa
Tom40 of Plasmodium knowlesi
*1.B.8.2.10









Porin protein of 368 aas

Eukaryota
Intramacronucleata
Porin protein of Tetrahymena thermophila
*1.B.8.2.11









Putative porin of 284 aas

Eukaryota
Fungi
Putative porin of Encephalitozoon cuniculi
*1.B.8.2.12









Entamoeba histolytica, an anaerobic intestinal parasite causing dysentery and extra-intestinal abscesses in humans, possesses highly reduced and divergent mitochondrion-related organelles (MROs) called mitosomes. This organelle lacks many features associated with canonical aerobic mitochondria and even other MROs such as hydrogenosomes. The Entamoeba mitosome has been found to have a compartmentalized sulfate activation pathway, which has a role in amebic stage conversion. It also features a unique shuttle system that delivers proteins from the cytosol to the mitosome. Only Entamoeba mitosomes possess a novel subclass of β-barrel outer membrane protein called MBOMP30.The mitosome protein import complex consisting of at least two proteins, TOM40, which provides the channel, and TOM60, which seems to be necessary for protein import (Makiuchi et al. 2013; Santos et al. 2016).

Eukaryota
Entamoebidae
TOM40/TOM60 of Entamoeba histolytica
*1.B.8.3.1









Putative mitochondrial porin of 309 aas (Porin3_VDAC superfamily)

Eukaryota
Intramacronucleata
MPP family member of Tetrahymena thermophila (Q22Z08)
*1.B.8.3.2









Mitochondrial porin of 305aas (Porin3_VDAC superfamily).  Exhibits the properties of a voltage-dependent general diffusion porin with cation-selectivity and a pore diameter of 1.3 nm (Ludwig et al. 1989).

Eukaryota
Intramacronucleata
MPP family member of Paramecium tetraurelia (Q3SE03)
*1.B.8.3.3









Putative mitochondrial porin of 301aas (Porin3_VDAC superfamily)

Eukaryota
Intramacronucleata
MPP family member of Oxytricha trifallax (J9JBL0)
*1.B.8.4.1









VDAC homologue of 277 aas

Eukaryota
Kinetoplastida
VDAC of Leishmania mexicana
*1.B.8.5.1









VDAC homologue

Eukaryota
Apicomplexa
VDAC of Theileria orientalis
*1.B.8.5.2









VDAC homologue

Eukaryota
Apicomplexa
VDAC of Plasmodium falciprarum
*1.B.8.6.1









The Mdm10 protein of 493 aas, a putative eukaryotic porin.  It belongs to the eukaryotic porin 3 superfamily together with VDAC and Tom40 (Flinner et al. 2013).  This protein is also listed under TC# 1.B.33.3.1 and TC#9.B.58.1.1 as part of two complexes: the mitochondrial Sorting and Assembly Machinery (SAM) and the TULIP complex, respectively.

Eukaryota
Fungi
Mdm10 of Saccharomyces cerevisiae
*1.B.8.6.2









Mdm10 protein of 646 aas

Eukaryota
Fungi
Mdm10 of Ustilago maydis
*1.B.8.6.3









Mdm10 protein of 317 aas

Eukaryota
Longamoebia
Mdm10 of Acanthamoeba castellanii
*1.B.8.6.4









Uncharacterized protein of 323 aas

Eukaryota
Dictyosteliida
Mdm10 of Dictyostelium discoideum
*1.B.8.6.5









Uncharacterized protein of 435 aas

Eukaryota
Fungi
UP of Pyrenophora tritici-repentis
*1.B.8.7.1









Porin protein of 290 aas

Eukaryota
Euglenida
Porin protein of Euglena gracilis