1.B.83. The Alpha-Aminoxy Acid Channel (AAAC) Family
Chemists have developed peptidomimetic foldamers, unnatural oligomeric molecules that fold into rigid and well-defined secondary structures, mimicking the structures and biological functions of these natural peptides. Li et al. 2008 designed peptidomimetic foldamers that give predictable, backbone-controlled secondary structures, irrespective of the nature of the side chains. α-aminoxy acid units were used to construct a synthetic Cl- channel that mediates the passage of Cl- ions across cell membranes (Li et al. 2008).