TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.109.1.1









Hemolysin A, TlyA of 240 aas

Bacteria
Spirochaetes
TlyA of Brachyspira (Serpulina) hyodysenteriae
*1.C.109.1.2









S-Hemolysin of 271 aas (Rajesh et al. 2013).

Bacteria
Actinobacteria
S-Hemolysin of Streptomyces coelicolor
*1.C.109.1.3









Putative hemolysin of 253 aas, TlyA.  In one study hemolysin activity was not detected, but adhsion to Caco cells was demonstrated (Sałamaszyńska-Guz and Klimuszko 2008).

Bacteria
Proteobacteria
TlyA of Campylobacter jejuni
*1.C.109.1.4









Hemolysin and RNA methyltransferase of 268 aas, TlyA (Rahman et al. 2010; Monshupanee 2013).  The assignment of this protein as an hemolysin has be questioned (Monshupanee 2013).  The assignment of this protein as an hemolysin has be questioned (Arenas et al. 2011).

Bacteria
Actinobacteria
TlyA of Mycobacterium tuberculosis
*1.C.109.1.5









Haemolysin III, TlyA family member of 279 aas (Ramarao and Sanchis 2013).

Bacteria
Firmicutes
Haemolysin of Bacillus cereus
*1.C.109.1.6









The 'non-conventional' hemolysin, TlyA, a pore-forming hemolysin with potent cytotoxic activity, is of 235 aas (Javadi and Katzenmeier 2016).  It causes agglutination, fusion and permeability of synthetic liposome vesicles. Agglutination activity could also be observed with erythrocytes before the induction of its pore-forming hemolytic activity. TlyA also induces disruption of liposome membranes (Lata and Chattopadhyay 2014).

Bacteria
Proteobacteria
TlyA of Helicobacter pylori