TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.111.1.1









Regenerating islet-derived protein 3-γ precursor, RegIIIγ (174aas)

Eukaryota
Metazoa
RegIIIγ of Mus musculus (O09049)
*1.C.111.1.2









Regenerating islet-derived protein 3α, RegIIIα or Reg3A.  Also called Proliferation-induced Protein 34, PAP or HIP of 157 aas.  It is a C-type intestinal lectin and forms hexameric pores in Gram-positive bacterial membranes.  The 3-d x-ray structure is known (Mukherjee et al. 2014).  Lipopolysaccharides inhibit pore formation, and hence, Gram-negative bacteria are usually not susceptible to its killing action (Mukherjee et al. 2014). 

Eukaryota
Metazoa
RegIIIα of Homo sapiens
*1.C.111.1.3









C-type lectin of 160 aas

Eukaryota
Metazoa
Lectin of Morelia spilota (Carpet python)
*1.C.111.1.4









SnEchinoidin of 192 aas

Eukaryota
Metazoa
SnEchinoidin of Mesocentrotus nudus
*1.C.111.1.5









Type II antifreeze protein of 192 aas

Eukaryota
Metazoa
Antifreeze protein of Lates calcarifer
*1.C.111.1.6









C-type lectin 1 of 155 aas

Eukaryota
Metazoa
C-type lectin of Perca flavescens
*1.C.111.1.7









Lactose-binding lectin I-2 of 181 aas

Eukaryota
Metazoa
Lectin I-2 of Ictalurus furcatus
*1.C.111.1.8









C-type lectin precursor of 177 aas

Eukaryota
Metazoa
C-type lectin of Lachesis muta
*1.C.111.1.9









C-type lecting domain family #4 member D of 205 aas

Eukaryota
Metazoa
Lectin of Chelonia mydas
*1.C.111.1.10









C-type lectin 5 of 153 aas

Eukaryota
Metazoa
Lectin of Azumapecten farreri
*1.C.111.1.11









Lectin-like transmembrane protein of 273 aas and 1 N-terminal TMS

Eukaryota
Metazoa
Lectin-like transmembrane protein of Mus musculus
*1.C.111.1.12









Dendritic cell natural killer lectin group receptor 1, DNGR-1, of 238 aas and 1 N-terminal TMS. It is also called C-type lectin domain family 9 member A (Cle9a). It functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells (Sancho et al. 2009). It recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged. It mediates the cross-presentation of dead-cell associated antigens in a Syk-dependent manner (Sancho et al. 2009; ). DNGR-1 is a receptor expressed by certain dendritic cell (DC) subsets and by DC precursors in the mouse. It possesses a C-type lectin-like domain (CTLD) followed by a poorly characterized neck region coupled to a transmembrane region and short intracellular tail. The CTLD of DNGR-1 binds F-actin exposed by dead cell corpses and causes the receptor to signal and potentiate cross-presentation of dead cell-associated antigens by DCs.The neck region of DNGR-1 is an integral receptor component that senses receptor progression through the endocytic pathway and has evolved to maximize extraction of antigens from cell corpses (HanĨ et al. 2016).

Eukaryota
Metazoa
DNGR-1 of Mus musculus (Mouse)
*1.C.111.1.13









NKG2-D type II protein of 216 aas and 1 central TMS. Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity (Zafirova et al. 2011). It stimulates perforin-mediated elimination of ligand-expressing tumor cells; signaling involves calcium influx, culminating in the expression of TNF-alpha (Zuo et al. 2017).

Eukaryota
Metazoa
NKG2-D of Homo sapiens