TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.2.1.1









ICP Cry1Aa. Cry1A (Receptors in Lepidoptera are cadherin-like proteins (Fabrick et al., 2009)). The pore-forming mechanism has been studied by Groulx et al. (2010).  Causes necrosis in Drosophila species (Obata et al. 2015).

Bacteria
Firmicutes
CryIAa of Bacillus thuringiensis (P0A367)
*1.C.2.1.2









Pesticide crystal protein Cry4Ba (δ-endotoxin) (1136aas) (Cadherin AgCad1 is the receptor for Cry4Ba (Hua et al., 2008)).
Bacteria
Firmicutes
Cry4Ba of Bacillus thuringiensis (P05519)
*1.C.2.1.3









Pesticidal pre-pore-forming crystal protein, Cry1Ab; insecticidal endotoxin (1155 aas). (90% identical to Cry1Aa; (1.C.2.1.1) Kills Manduca sexta. There are several receptors (Arenas et al., 2010).  Also called bt2, Cry1-2, Cry1A(b) and CryIC1.  Mutations affecting pre-pore oligomerization and toxin pore formation have been described (Jiménez-Juárez et al. 2007).

Bacteria
Firmicutes
Cry1Ab of Bacillus thuringiensis (P0A370)
*1.C.2.1.4









Cry1Ac (85% identical to Cry1Aa (TC#1.C.2.1.1). May use MRP-4-like ABC transporter as a receptor in Bombyx mori (Atsumi et al., 2012).

Bacteria
Firmicutes
Cry1Ac of Bacillus thuringiensis (D3XF72)
*1.C.2.1.5









Pesticidal crystal protein of 1144 aas, Cry8.

Bacteria
Firmicutes
Cry8 of Bacillus thurengiensis
*1.C.2.1.6









The Cry8Ea1 toxin of 1164 aas.  The 2.2-Å crystal structure has been reported (Guo et al. 2009). Cry8Ea1 is specifically toxic to the underground larvae of Holotrichia parallela (Jia et al. 2014).

Bacteria
Firmicutes
Cry8Ea1 of Bacillus thuringiensis
*1.C.2.1.7









Pesticidal crystal protein (ICP) Cry3Aa (Andreev et al., 2009).

Bacteria
Firmicutes
Cry3Aa of Bacillus thuringiensis (P0A380)
*1.C.2.1.8









Parasporin 1, PS1 or Cry41Aa of 825 aas (Akiba and Okumura 2016). Also called Cancer cell-killing Cry protein, parasporin-3.

Bacteria
Firmicutes
PS1 of Bacillus thuringiensis
*1.C.2.2.1









Insecticidal crystal protein, Cry11Aa of 643 aas.  Cry and Cyt toxins are both oligomeric pore-formers that act synergistically with each other via direct protein-protein interactions (López-Diaz et al. 2013). Target tissue cellular responses to the toxin have been determined (Canton et al. 2015).

Bacteria
Firmicutes
Cry11Aa of Bacillus thuringiensis
*1.C.2.3.1









Pesticidal crystal protein (ICP) Cry13Aa

Bacteria
Firmicutes
Cry13Aa of Bacillus thuringiensis (Q45755)
*1.C.2.3.2









Delta-endotoxin, Cry5B, of 1245 aas is lethal to nematodes. Active Cry5B can be expressed intracellularly in and released extracellularly from Lactococcus lactis via a holin, showing potential for future use as an anthelminthic that could be delivered orally in a food-grade microbe. (Durmaz et al. 2015). 

Bacteria
Firmicutes
Cry5B of Bacillus thuringiensis