TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.35.1.1









Amoebapore A
Eukaryota
Entamoeba
Amoebapore A of Entamoeba histolytica
*1.C.35.1.2









Amoebapore B
Eukaryota
Entamoeba
Amoebapore B of Entamoeba histolytica
*1.C.35.1.3









Amoebapore C
Eukaryota
Entamoeba
Amoebapore C of Entamoeba histolytica
*1.C.35.1.4









Nonpathogenic pore-forming peptide precursor, APNP
Eukaryota
Entamoeba
APNP of Entamoeba histolytica
*1.C.35.1.5









Pore-forming protein-like protein of 79 aas, saposin B type, SapB

Eukaryota
Metazoa
SapB of Steinernema carpocapsae (Entomopathogenic nematode)
*1.C.35.2.1









Cerebroside sulfate activator protein, CSAP or prosaposin (PSAP, GLBA, SAP1) of 524 aas. Saposin A, B, C and D are derived from prosaposin by proteolysis. Saposin-A and C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipids to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by β-galactosidase and globotriaosylceramide by α-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator. Prosaposin behaves as a myelinotrophic and neurotrophic factor; these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling (Hiraiwa et al. 1999).

Eukaryota
Metazoa
CSAP of Homo sapiens
*1.C.35.2.2









Saposin-like protein (Saplip C; SalA) of157 aas.  Important for lipid interactions and lysosomal degradation of several sphingolipids (Vaccaro et al. 1999).

Eukaryota
Dictyosteliida
Saplip C of Dictyostelium discoideum (Slime mold)
*1.C.35.2.3









Saposin of 254 aas and 1 N-terminal TMS (Hao et al. 2010).

Eukaryota
Metazoa
Saposin of Steinernema carpocapsae (Entomopathogenic nematode)
*1.C.35.3.1









 Antimicrobial natural killer cell lysin, NK-lysin of 129 aas.  NK-lysin is involved in the inducible cytotoxicity of T and NK cells (Andersson et al. 1996).

Eukaryota
Metazoa
NK lysin of Sus scrofa
*1.C.35.3.2









Granulosin of 145 aas and 1 TMS.  Functions probably by pore-formation by natural killer (NK) and T lympocyces to combat intracellular parasites, both bacterial and eukaryotic (Dotiwala et al. 2016).

Eukaryota
Metazoa
Granulosin of Homo sapiens
*1.C.35.4.1









Countin
Eukaryota
Dictyosteliida
Countin of Dictyostelium discoideum