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1.C.35.3.1
 Antimicrobial natural killer cell lysin, NK-lysin of 129 aas.  NK-lysin is involved in the inducible cytotoxicity of T and NK cells (Andersson et al. 1996).

Accession Number:Q29075
Protein Name:NKL
Length:129
Molecular Weight:14317.00
Species:Sus scrofa (Pig) [9823]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Pfam: PF05184    PF03489   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042742 P:defense response to bacterium
GO:0050832 P:defense response to fungus
GO:0031640 P:killing of cells of another organism
GO:0006629 P:lipid metabolic process

References (2)

[1] “NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.”  Andersson M.et.al.   7737114
[2] “Saposin fold revealed by the NMR structure of NK-lysin.”  Liepinsh E.et.al.   9334742
Structure:
1NKL     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	PGLAFSGLTP EHSALARAHP CDGEQFCQNL APEDPQGDQL LQREELGLIC ESCRKIIQKL 
61:	EDMVGPQPNE DTVTQAASRV CDKMKILRGV CKKIMRTFLR RISKDILTGK KPQAICVDIK 
121:	ICKEKTGLI