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1.C.4.4.1
Hydralysin (Sher et al., 2005; Zhang et al., 2003).  Hydrolysins comprise a family of pore-forming proteins that are secreted into the gastrovascular cavity during feeding, probably helping in disintegration of the prey (Sher and Zlotkin 2009). Induces an immediate fast muscle contraction followed by flaccid paralysis when injected into blowfly larvae. The paralytic effect is lower in mice and fish. Has strong cytolytic activity against insect Sf9 cells and human HeLa cells. Binds to erythrocyte membranes and has weak hemolytic activity by mediating oligomerization and pore formation (Zhang et al. 2003; Sher et al. 2008).

Accession Number:Q86LR2
Protein Name:Hydralysin
Length:244
Molecular Weight:26212.00
Species:Chlorohydra viridissima (Hydra) (Hydra viridis) [6082]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Gene Ontology

GO:0016020 C:membrane
GO:0044218 C:other organism cell membrane
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009405 P:pathogenesis

References (2)

[1] “Hydralysin, a novel animal group-selective paralytic and cytolytic protein from a noncnidocystic origin in hydra.”  Zhang M.et.al.   12885226
[2] “Hydralysins, a new category of beta-pore-forming toxins in cnidaria.”  Sher D.et.al.   15824108

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FASTA formatted sequence
1:	MGKELLTFSD LTWLDSSPDT VRSAFTREYG TTPDGIALNS EGYFGYHSPP ITEQYGRPCY 
61:	KQTGETKITL QELGPSTDAV LGNSTAVNRG DSSIDLTVSV EGKWSDSTSW STSTETGVKM 
121:	SSEFEVEGAF KMGGEFSLTL SVGKSGSSSV EKTSTSSVQV TVPPRSKVVV SMVGIMKKEK 
181:	VFFEVPVTVD GSFGANFPST VQGHYFWFMD ARSCLNKTSG VIKGTIDHAN VFDVSVEVGP 
241:	SEPL