TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.42.1.1









Bacillus anthracis protective antigen (PA). Many cationic compounds inhibit in nM - mM concentration ranges (Yamini et al. 2016). Both symmetry and size of cyclodextrin inhibitors and the toxin pore are important for effective inhibition (Yannakopoulou et al., 2011).  A cryo electron microscopic structure of the anthrax protective antigen translocon and the N-terminal domain of anthrax lethal factor inserted into a nanodisc model lipid bilayer has been solved revealing a cap, a narrow stalk and a transmembrane channel (Gogol et al. 2013).  Poly(amindo)amine (PAMAM) dentrimers block activity (Förstner et al. 2014).  The 3-d structure of PA, showing the channel and the φ-clamp, and providing information about the multi-step mechanism by which low pH is sensed and the membrane-spanning channel is formed has been published (Jiang et al. 2015).  The export of the lethal factor and edema factor from the endosome into the host cytosol is dependent on the proton motive force (pmf) (Colby and Krantz 2015).

Bacteria
Firmicutes
PA of Bacillus anthracis
*1.C.42.1.2









C2II channel-forming toxin component.  Channel-formation is inhibited by azolopyridinium salts (Bronnhuber et al. 2014).

Bacteria
Firmicutes
C2II of Clostridium botulinum
*1.C.42.1.3









Iota toxin component Ib
Bacteria
Firmicutes
Iotatoxin Ib of Clostridium perfringens
*1.C.42.1.4









The Vegetative insecticidal protein 1A (Vip1)

Bacteria
Firmicutes
Vip1 of Bacillus thuringiensis
*1.C.42.1.5









The vegetative insecticidal protein 1A (Vip1A) (96aas)

Bacteria
Firmicutes
Vip1A of Bacillus thuringiensis
*1.C.42.1.6









Clostridium spiroforme toxin component Sb (Sbs) of 879 aas.

Bacteria
Firmicutes
Sbs of Clostridium spiroforme
*1.C.42.1.7









Clostridium spirofore toxin component Sa (Sas) of 459 aas.

Bacteria
Firmicutes
Sas of Clostridium spirofore