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Calcitonin gene regulatory peptide I precursor, CGRPI of 128 aas and 1 - 3 TMSs. CGRP induces vasodilation, dilating a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS points toward a neurotransmitter or neuromodulator role (Kitamura et al. 1992). It also elevates platelet cAMP and elevates calcium while polarizing the membrane potential by both cAMP-independent and -dependent mechanisms (Burns et al. 2004).  

Accession Number:P06881
Protein Name:CAL1 aka CGRPI aka CALCA aka CALC1
Molecular Weight:13899.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Secreted1
Substrate K+, Na+, Ca2+, Cl-

Cross database links:

Genevestigator: P06881
RefSeq: NP_001029125.1   
Entrez Gene ID: 796   
Pfam: PF00214   
OMIM: 114130  gene

Gene Ontology

GO:0005737 C:cytoplasm
GO:0005615 C:extracellular space
GO:0005179 F:hormone activity
GO:0007190 P:activation of adenylate cyclase activity
GO:0007267 P:cell-cell signaling
GO:0051482 P:elevation of cytosolic calcium ion concentr...
GO:0043542 P:endothelial cell migration
GO:0001935 P:endothelial cell proliferation
GO:0007159 P:leukocyte cell-cell adhesion
GO:0045776 P:negative regulation of blood pressure
GO:0045779 P:negative regulation of bone resorption
GO:0010523 P:negative regulation of calcium ion transpor...
GO:0045671 P:negative regulation of osteoclast different...
GO:0001976 P:neurological system process involved in reg...
GO:0032730 P:positive regulation of interleukin-1 alpha ...
GO:0032757 P:positive regulation of interleukin-8 produc...
GO:0045651 P:positive regulation of macrophage different...
GO:0045909 P:positive regulation of vasodilation
GO:0001944 P:vasculature development

References (11)

[1] “Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.”  Jonas   3872459
[2] “Structure and methylation of the human calcitonin/alpha-CGRP gene.”  Broad   2571128
[3] “Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.”  Nelkin   6148938
[4] “Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.”  Edbrooke   2408883
[5] “Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma.”  Steenbergh   6610687
[6] “Expression and function of the human calcitonin/alpha-CGRP gene in health and disease.”  Craig   3034287
[7] “Isolation and characterization of human calcitonin gene-related peptide.”  Morris   6609312
[8] “Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord.”  Petermann   3492492
[9] “Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.”  Kitamura   1318039
[10] “Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.”  Breeze   1988044
[11] “Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin.”  Hubbard   2039456
1LS7   6E3Y     

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