1.C.53 The Lactocyclicin Q (Lactocyclicin Q) Family
Lactococcus sp. strain QU 12, isolated from cheese, produces a cyclic bacteriocin termed lactocyclicin Q (Sawa et al., 2009). Lactocyclicin Q was purified from culture supernatant and has a unique antimicrobial spectrum, high level of protease resistance, and heat stability compared to other reported bacteriocins of lactic acid bacteria. This compound is composed of 61 aas that have a cyclic structure with linkage between the N and C termini by a peptide bond. It shows little similarity to any other antimicrobial peptides, including cyclic bacteriocins, but shows significant similarity to small proteins from Bacillus coagulans (EEN93214; 38% identity) and Paenibacillus larvae (ZP_02326427; 36% identity). It has a single TMS.
The reaction presumed to be catalyzed by Lactocyclicin Q is:
ions (in) ⇌ ions (out)