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1.C.53 The Lactocyclicin Q (Lactocyclicin Q) Family

Lactococcus sp. strain QU 12, isolated from cheese, produces a cyclic bacteriocin termed lactocyclicin Q (Sawa et al., 2009). Lactocyclicin Q was purified from culture supernatant and has a unique antimicrobial spectrum, high level of protease resistance, and heat stability compared to other reported bacteriocins of lactic acid bacteria. This compound is composed of 61 aas that have a cyclic structure with linkage between the N and C termini by a peptide bond. It shows little similarity to any other antimicrobial peptides, including cyclic bacteriocins, but shows significant similarity to small proteins from Bacillus coagulans (EEN93214; 38% identity) and Paenibacillus larvae (ZP_02326427; 36% identity). It has a single TMS.

The reaction presumed to be catalyzed by Lactocyclicin Q is:

ions (in) ⇌ ions (out)

This family belongs to the: Bacterial Bacteriocin (BB) Superfamily.

References associated with 1.C.53 family:

Sawa, N., T. Zendo, J. Kiyofuji, K. Fujita, K. Himeno, J. Nakayama, and K. Sonomoto. (2009). Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus sp. strain QU 12. Appl. Environ. Microbiol. 75: 1552-1558. 19139222
van Belkum, M.J., L.A. Martin-Visscher, and J.C. Vederas. (2011). Structure and genetics of circular bacteriocins. Trends Microbiol. 19: 411-418. 21664137
Wescombe, P.A., M. Upton, P. Renault, R.E. Wirawan, D. Power, J.P. Burton, C.N. Chilcott, and J.R. Tagg. (2011). Salivaricin 9, a new lantibiotic produced by Streptococcus salivarius. Microbiology 157: 1290-1299. 21310787