TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.63.1.1









Spider venom α-latrotoxin of 1401 aas, α-LTX. It induces massive exocytosis after binding to a surface receptor, latrophilin (LPH). In this process, it first induced membrane depolarization by inhibition of repolarizing K+ channels followed by the appearance of Ca2+ transients. In a second phase, the toxin induced a large inward current and a prominent increase in intracellular calcium ions, reflecting pore formation (Lajus et al. 2006).

Eukaryota
Metazoa
α-latrotoxin from Latrodectus mactans
*1.C.63.1.2









α-latroinsectotoxin precursor (α-LIT) (1411aas) (Shatursky et al., 2007)
Eukaryota
Metazoa
α-LIT of Latrodectus mactans (Q02989)
*1.C.63.1.3









α-latrocrustotoxin-Lt1a-like protein of 722 aas.

Eukaryota
Metazoa
Lt1a of Parasteatoda tepidariorum