TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.73.1.1









Pore-forming exotoxin A (chain A; ExlA)  (Rasper and Merrill 1994; Méré et al., 2005).  Pore-formation has been demonstrated (Zalman and Wisnieski 1985).  Secretion depends on ExlB, a Two Partner Secretion (TPS; TC# 1.B.20) system, as well as type IV pili.  The protein has three domains: an N-terminal hemolyin domain, a central RGD motif domain, and a C-terminal domain required for cell lysis.  Pore-formation precedes lysis (Basso et al. 2017). ExlA triggers cadherin cleavage by promoting calcium influx which activates ADAM10 for proteolysis (Reboud et al. 2017).

Bacteria
Proteobacteria
Exotoxin A (ExlA) of Pseudomonas aeruginosa (P11439)
*1.C.73.1.2









The cholix toxin.  The NAD-dependent ADP-ribosyltransferase (ADPRT) catalyzes transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2), thus arresting protein synthesis. It may use the eukaryotic pro-low-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells,  Cholix toxin shares structural and functional properties with Pseudomonas aeruginosa exotoxin A and Corynebacterium diphtheriae diphtheria toxin (Lugo and Merrill 2015).

Bacteria
Proteobacteria
Cholix toxin of Vibrio cholera
*1.C.73.1.3









Exotoxin A of 241 aas

Bacteria
Proteobacteria
Exotoxin A of Cystobacter fuscus
*1.C.73.2.1









Uncharacterzed protein of 679 aas

Bacteria
Proteobacteria
UP of Yersinia frederiksenii
*1.C.73.2.2









Exotoxin of 806 aas

Bacteria
Proteobacteria
Exotoxin of Yersinia similis
*1.C.73.3.1









Uncharacterized protein of 698 aas

Bacteria
Actinobacteria
UP of Mycobacterium gastri
*1.C.73.3.2









Uncharacterized toxin of 736 aas.

Bacteria
Acidobacteria
Toxin of Chloracidobacterium thermophilum
*1.C.73.3.3









Putative toxin of 937 aa

Bacteria
Planctomycetes
*1.C.73.3.4









Putative toxin of 679 aas

Bacteria
Cyanobacteria
Toxin of Gloeocapsa sp. PCC 7428