TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.74.1.1









Cobra cardiotoxin-1 (cytotoxin CM-6), CTX1. It is a basic protein that binds to cell membrane s and depolarizes cardiomyocytes. It also possesses lytic activity on many cells, including red blood cells (Chien et al. 1994). Cytotoxicity is due to pore formation and to another mechanism independent of membrane-damaging activity (Wang et al. 2006).

Eukaryota
Metazoa
CTX1 of Naja naja (P60305)
*1.C.74.1.2









α-bungarotoxin isoform A31 (α-BTX A31) (blocks activity of the nicotinic acetylcholine receptor (TC #1.A.9)
Eukaryota
Metazoa
αBTX A31 of Bungarus multicinctus (P60615)
*1.C.74.1.3









β-cardiotoxin, CTX14, of 84 aas.

Eukaryota
Metazoa
CTX14 pf Ophiophagus hannah (King cobra) (Naja hannah)
*1.C.74.1.4









Long neurotoxin 43, LNTX43 of 108 aa

Eukaryota
Metazoa
LNTX-43 of Drysdalia coronoides (White-lipped snake) (Hoplocephalus coronoides)
*1.C.74.1.5









Bucain of 65 aas

Eukaryota
Metazoa
Bucain of Bungarus candidus (Malayan krait)
*1.C.74.1.6









3 finger muscarinic toxin, Mt1 of 66 aas. Shows a non-competitive interaction with adrenergic and muscarinic receptors. Binds to alpha-2b (ADRA2B) (IC50=2.3 nM), alpha-1a (ADRA1A), alpha-1b (ADRA1B), and alpha-2c (ADRA2C) adrenergic receptors. Reversibly binds to M1 (CHRM1) muscarinic acetylcholine receptors, probably by interacting with the orthosteric site.

Eukaryota
Metazoa
MT1 of Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
*1.C.74.1.7









α-elapitoxin 2a, Nno2a of 73 aas

Eukaryota
Metazoa
Nno2a of Naja oxiana (Central Asian cobra) (Oxus cobra)