TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.79.1.1









Histatin 3 precursor of 51 aas and 1 N-terminal TMS.  Histatins are salivary proteins that are major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C. albicans and C. neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P. gingivalis (Gusman et al. 2001; Tsai et al. 1996). The His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. It may kill cells by volume dysregulation and ion imbalance triggered by osmotic stress (Puri and Edgerton 2014). Histatins also promote wound healing (Torres et al. 2018).

Eukaryota
Metazoa
Histatin 3 of Homo sapiens (P15516)
*1.C.79.1.2









Statherin (isoform a) precursor; inhibits precipitation of CaPO4H salts (secreted by parotid and submandibular glands)
Eukaryota
Metazoa
Statherin of Homo sapiens (P02808)
*1.C.79.1.3









histatin-1, Htn1 of 57 aas and 1 N-terminal TMS.  functions as a tooth enamel constituent and as an antibacterial agent (Crosara et al. 2018).

Eukaryota
Metazoa
Histatin-1 of Homo sapiens
*1.C.79.1.4









Histatherin, HstN, isoform X2of 99 aas and 1 TMS/

Eukaryota
Metazoa
HstN of Bos taurus
*1.C.79.2.1









Uncharacterized protein of 60 aas and 1 or 2 TMSs.

Eukaryota
Metazoa
UP of Rhinopithecus roxellan
*1.C.79.3.1









Uncharacterized protein of 55 aas and 1 TMS.

Bacteria
Proteobacteria
UP of Paraburkholderia caballeronis