TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.8.1.1









Botulinum neurotoxin types A-G.  Poly(amindo)amine (PAMAM) detrimers block activity (Förstner et al. 2014).  BoNTs inhibit synaptic exocytosis; intoxication requires the di-chain protein to undergo conformational changes in response to pH and redox gradients across the endosomal membrane with consequent formation of a protein-conducting channel by the heavy chain (HC) that translocates the light chain (LC) protease into the cytosol, colocalizing it with the substrate SNARE proteins (Montal 2009).

Bacteria
Firmicutes
Botulinum neurotoxin precursor, type A of Clostridium botulinum
*1.C.8.1.2









Tetanus neurotoxin
Bacteria
Firmicutes
Tetanus neurotoxin precursor of Clostridium tetani
*1.C.8.1.3









Clostridium botulinum neurotoxin type E (3d structure known (Kumaran et al., 2009))

Bacteria
Firmicutes
BoNTE of Clostridium botulinum (Q00496)