TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.C.8.1.1









Botulinum neurotoxin types A-G.  Poly(amindo)amine (PAMAM) detrimers block activity (Förstner et al. 2014).  BoNTs inhibit synaptic exocytosis; intoxication requires the di-chain protein to undergo conformational changes in response to pH and redox gradients across the endosomal membrane with consequent formation of a protein-conducting channel by the heavy chain (HC) that translocates the light chain (LC) protease into the cytosol, colocalizing it with the substrate SNARE proteins (Montal 2009).

Bacteria
Firmicutes
Botulinum neurotoxin precursor, type A of Clostridium botulinum
*1.C.8.1.2









Tetanus neurotoxin
Bacteria
Firmicutes
Tetanus neurotoxin precursor of Clostridium tetani
*1.C.8.1.3









Clostridium botulinum neurotoxin type E (3d structure known (Kumaran et al., 2009))

Bacteria
Firmicutes
BoNTE of Clostridium botulinum (Q00496)
*1.C.8.1.4









Non-toxic nonhemagglutinin type C of 1196 aas.  Assembles with botulinum neurotoxin type C (BoNT/C) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0. The non-toxic component is necessary to maintain toxicity.

Viruses
Caudovirales
Nonhemagglutinin type C of Clostridium botulinum C phage (Clostridium botulinum C bacteriophage)