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1.C.85.1.3
β-defensin-3

Accession Number:P81534
Protein Name:β-defensin-3
Length:67
Molecular Weight:7697.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Genevestigator: P81534
eggNOG: prNOG21678
HEGENOM: HBG127022
RefSeq: NP_001075020.1    NP_061131.1   
Entrez Gene ID: 414325    55894   
Pfam: PF00711   
OMIM: 606611  gene
KEGG: hsa:414325    hsa:55894   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042742 P:defense response to bacterium
GO:0006965 P:positive regulation of biosynthetic process...

References (4)

[1] “Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic.”  Harder J.et.al.   11085990
[2] “Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction.”  Conejo-Garcia J.-R.et.al.   11702237
[3] “Discovery of new human beta-defensins using a genomics-based approach.”  Jia H.P.et.al.   11223260
[4] “The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus.”  Schibli D.J.et.al.   11741980
Structure:
1KJ6     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRIHYLLFAL LFLFLVPVPG HGGIINTLQK YYCRVRGGRC AVLSCLPKEE QIGKCSTRGR 
61:	KCCRRKK