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1.D.27 The Thiourea isosteres Family

Compounds containing cyanoguanidine and 3-amino-1,2,4-benzothiadiazine-1,1-dioxide have been studied as anion receptors and transporters. Significant affinity for oxo-anions was observed in organic solution and the receptors were found to function as transmembrane chloride/nitrate antiporters with transport rates enhanced in the presence of a valinomycin-K+ complex (Wenzel et al., 2011).

The generalized reaction catalyzed by these compounds is: 

Anions (in) ⇌ Anions (out)

References associated with 1.D.27 family:

Wenzel, M., M.E. Light, A.P. Davis, and P.A. Gale. (2011). Thiourea isosteres as anion receptors and transmembrane transporters. Chem Commun (Camb) 47: 7641-7643. 21655625