1.D.27 The Thiourea isosteres Family
Compounds containing cyanoguanidine and 3-amino-1,2,4-benzothiadiazine-1,1-dioxide have been studied as anion receptors and transporters. Significant affinity for oxo-anions was observed in organic solution and the receptors were found to function as transmembrane chloride/nitrate antiporters with transport rates enhanced in the presence of a valinomycin-K+ complex (Wenzel et al., 2011).
The generalized reaction catalyzed by these compounds is:
Anions (in) ⇌ Anions (out)